Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Effects of Hwangryeonhaedoktang on Depression and c-Fos Expression in Paraventricular Nucleus of the Brain in the Chronic Mild Stress Treated Rats

황련해독탕(黃連解毒湯)이 우울증 모형 동물의 우울성향 및 PVN의 c-Fos 발현에 미치는 효과

  • Chung, Sun-Yong (Department of Neuropsychiatry, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Jong-Woo (Department of Neuropsychiatry, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Jung-Ryun (Department of Psychology, Korea University) ;
  • Jang, Hyun-Ho (Department of Psychology, Korea University) ;
  • Kim, Hyun-Taek (Department of Psychology, Korea University) ;
  • Whang, Wei-Wan (Department of Neuropsychiatry, College of Oriental Medicine, Kyung Hee University)
  • 정선용 (경희대학교 한의과대학 신경정신과 교실) ;
  • 김종우 (경희대학교 한의과대학 신경정신과 교실) ;
  • 이정륜 (고려대학교 심리학과) ;
  • 장현호 (고려대학교 심리학과) ;
  • 김현택 (고려대학교 심리학과) ;
  • 황의완 (경희대학교 한의과대학 신경정신과 교실)
  • Published : 2003.06.30
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Abstract

Objective : This study was designed to assess the protective effects of Hwangryeonhaedoktang on the animal model of depression, induced by chronic mild stress(CMS). Method : Male Sprague-Dawley rats were used for this experiment. The subjects were divided into 3 groups ( 1. CMS-drug: Hwangryeonhaedoktang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment, they were executed forced swimming test(FST), open field test and c-Fos in paraventricular nucleus(PVN) were measured. Result : 1. In FST, immobility behavior decreased significantly in CMS-drug group. 2. There was no difference in the open field test between 3 groups 3. c-Fos expressed cell bodies in PVN were significantly less in CMS-drug than in CMS-vehicle group. Conclusion : These results suggest that Hwangryeonhaedoktang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus.

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