Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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A Study of Jowiseungchungtang in patients with mild Dementia of Alzheimer type

조위승청탕(調胃升淸湯)이 초기 Dementia of Alzheimer type 환자의 인지기능 변화에 미치는 효과

  • Cho, Seung-Hun (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Jong-Woo (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Hyun-Taek (Dept. of Psychology, Korea University) ;
  • Chung, Kyung-Chun (Dept. of Neurology, Kyunghee University) ;
  • Whang, Wei-Wan (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyunghee University)
  • 조성훈 (경희대학교 한의과대학 한방신경정신과학 교실) ;
  • 김종우 (경희대학교 한의과대학 한방신경정신과학 교실) ;
  • 김현택 (고려대학교 심리학과) ;
  • 정경천 (경희대학교 의과대학 신경과학 교실) ;
  • 황의완 (경희대학교 한의과대학 한방신경정신과학 교실)
  • Published : 2003.06.30
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Abstract

Objective : The clinical efficacy of Jowiseungchungtang(oriental herbal medication) over 6-month on the cognitive function in patients with mild Dementia of Alzheimer type(DAT) was investigated in this study. Method : The subjects for this study consisted of dementia patients who visited to the outpatient dementia department of Oriental Neuropsychiatry of the Kyunghee Oriental hospital. Patients were required to have at entry: a dignosis of mild DAT; Biochemical test, CBC, Urine analysis, Chest X -ray, EKG, Brain- MRI, Mini-Mental States-Korea(MMSE-K), Korean-Dementia Rating Scale(K-DRS), Samsung Dementia Questionaire(SDQ;to their caregiver). Patients(n=31) were assigned to treatment with Jowiseungchungtang (fourth/day for 6-month). The primary outcome measure was K-DRS. Result : 1. Patients' mean age was $71.4{\pm}6.6$ years(range 59 to 86 years). 2. Patients' mean education was $6.1{\pm}4.9$ years. K-DRS scores at baseline was $110.5{\pm}12.2$. K-DRS scores at 6-month was $109.0{\pm}17.0$. K-DRS scores at 6-month was not significantly different with K-DRS scores at baseline(t=.791 r=.435 p<.05). Conclusion : Treatment with Jowiseungchungtang for 6-month protected the cognitive function decline in patients with mild DAT.

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