Journal of Oriental Neuropsychiatry (동의신경정신과학회지)
- Volume 14 Issue 1
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- Pages.45-58
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- 2003
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- 1226-6396(pISSN)
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- 2234-4942(eISSN)
Effects of Morinda officinalis (MDOF) on Inhibition of Impairment of Learning and Memory, and Acetylcholinesterase in Amnesia Mice
파극천(巴戟天)이 치매병태모델에 미치는 영향(影響)
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Jung, In-Chul
(Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
;
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Lee, Sang-Ryong
(Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
;
- Kim, Hyun-Soo (Department of Oriental Neuropsychiatry, College of Oriental Medicine, Daejeon University)
- Published : 2003.06.30
Abstract
Alzheimer's disease(AD) is progressive neurodegenerative disease, which is pathologically characterized by neuritic plaques and neurofibrillary tangles associated with the acetylcholinesterase, apolipoprotein E and butylcholinesterase, and by mutations in the presenilin genes PS1 and PS2, and amyloid precursor proteins (APP) overexpression. The present research is to examine the inhibition effect of MDOF on PS-1, PS-2 and APP overexpression by detected to Western blotting. To verify the effects of MDOF on cognitive deficits further, we tested it on the scopolamine-induced amnesia model of the mice using the Morris water maze tests, and there was ameliorative effects of memory impairment as a protection to scopolamine. MDOF only partially blocked the increase in blood serum level of acetylcholinesterase and Uric acid induced by scopolamine, whereas blood glucose level was shown to attenuate the amnesia induced by scopolamine and inreased extracelluar serum level compared with only scopolamine injection. In conclusion, studies of MDOF that has been know as anti-choline and inhibition ablilities of APP overexpression, this could also be used further as a important research data for a preventive and promising symptomatic treatment for Alzheimer's disease.