Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Effect of Deer Blood on Reduction of the Side Effects of Chemotherapeutic Drugs

녹혈의 화학요법 항암제 부작용 억제 효능

  • Kim, Han-Seob (Baek Woon Dang Oriental Clinic) ;
  • Hong, Soon-Bok (Dept. of Medical R&D, Korea Institute of Oriental Medicine) ;
  • Sung, Hyun-Jea (College of Oriental Medicine, Semyung University) ;
  • Moon, Geun-Ah (Dept. of Medical R&D, Korea Institute of Oriental Medicine) ;
  • Yoon, Yoo-Sik (Dept. of Medical R&D, Korea Institute of Oriental Medicine)
  • 김한섭 (백운당한의원) ;
  • 홍순복 (한국한의학연구원 의료연구부) ;
  • 성현제 (세명대학교 한의과대학) ;
  • 문근아 (한국한의학연구원 의료연구부) ;
  • 윤유식 (한국한의학연구원 의료연구부)
  • Published : 2003.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Many chemotherapeutic drugs were developed and contributed to the increase of cure rate of cancer, however severe side effect of these drugs is a major cause of poor quality of life of cancer patients. Effect of deer blood on cancer therapy was investigated in mouse tumor model. Deer blood itself was shown to have mild antitumor activity. However it has significant effect on the reduction of the side effects of chemotherapy. Deer blood recovered the reduction of WBC and platelet (myelotoxicity) during fluorouracil chemotherapy. Deer blood also recovered the increase of serum blood urea nitrogen (BUN; indicator of renal toxicity) and increase of serum amylase activity (AMY; indicator of pancreatic toxicity) almost to the control level during cisplatin chemotherapy. Fluorouracil and cisplatin are major chemotherapeutic drugs which are currently used in clinical cancer therapy, and the results strongly suggest that deer blood can be used for reducing the side effects and improving the quality of life during chemotherapy of cancer patients.

Keywords

References

  1. Skeel, R.T. and Ganz, P.A. (1999) Systematic assessment of the patient with cancer and long-term medical complications of treatment. In Skeel, R.T. (ed.), Handbook of cancer chemotherapy, 34-55. Lippincott Williams & Wilkins, Philadelpia, PA
  2. Duschinsky, R, Pleven, E. and Heidelberg, C. (1957) The synthesis of 5-fluorouracil. J. Am. Chern. Soc. 79: 4559-4560
  3. Skeel, R.T. (1999) Antineoplastic drugs and biological response modifiers. In Skeel, R.T. (ed.), Handbook of cancer chemotherapy, 108-109. Lippincott Williams & Wilkins, Philadelpia, PA
  4. Skeel, R.T. (1999) Antineoplastic drugs and biological response modifiers. In Skeel, R.T. (ed.), Handbook of cancer chemotherapy, 89-91. Lippincott Williams & Wilkins, Philadelpia, PA
  5. 최평낙, 김광호(1987) 녹각이 methotrezate로 유발된 면역 저하에 미치는 영향. 경희한의대 논문집 10: 589-604
  6. 김현식, 허인회. 이상준, 안형수(1994) 녹각추출액의 면역학적 특성에 관한연구. 약학회지 38: 806-813
  7. 허준(1613) 대역 동의보감. p.1840. 법인문화사, 서울
  8. 신문풍출판공사(1971) 신편 중약대사전. p1927. 신문풍출판공사, 북경
  9. 박갑주, 홍순복, 김은해, 마진열, 은영아, 김한섭(1998) 녹혈이 cyclophosphamide로 유도된 악성빈열의 조혈기능 촉진에 미치는 영향. kor. J Pharmacogn. 29(4): 283-292
  10. Sugiyama, K., Ueda, H., Ichio, Y, and Yokota, M. (1995) Improvement of cisplatin toxicity and lethality by Juzentaiho- to in mice. Biol. Pharm. Bull. 18(1): 53-58. https://doi.org/10.1248/bpb.18.53
  11. 金井 泉, 金井 正兆(1993) 임상검사법제요. 고문사, 서울