Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of Antimicrobial Activity from the Marine-Derived Fungus

해양균류의 항균활성 검색

  • Li, Yong (Department of Chemistry, Pukyong National University) ;
  • Li, Xifeng (Department of Chemistry, Pukyong National University) ;
  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
  • Published : 2003.06.30
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Abstract

Acetone extracts of 301 strains of marine-derived fungus were tested for antimicrobial activity against three strains of bacteria. The bacteria consisted of three pathogens, Staphylococcus aureus, methicillin-resistant S. Aureus, and multidrug-resistant S. aureus. The acetone extracts of 10 strains (MFA117, MFA130, MFA134, MFA206, MFA217, MFA268, MFA277, MFA291, MFA292, MFA301) showed strong activity, inhibiting 100% of the bacterial growth. These antimicrobial active strains were cultlued in SWS medium on a 1 L scale and the resulting broth and mycelium were extracted to afford mycelium extract (000M) and broth extract (000B), respectively. Antimicrobial activity for all extracts has been tested as the results, the mycelium extract of one strain (217M) and the broth extracts of 9 strains (117B,130B, 134B, 206B, 268B, 277B, 291B, 292B, 301B) exhibited relatively high levels of activity at minimal inhibitory concentration (MIC) values of $500-125\;{\mu}g/mL$ range. Among them, the extracts, 277B, 291B, 292B and 301B showed the most significant antimicrobial activity with $IC_{50}$ values of $125\;{\mu}g/mL$.

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References

  1. Fenical, W. (1993) Chemical studies of marine bacteria: developing a new resource. Chern, Rev., 93(5): 1673-1683 and references therein https://doi.org/10.1021/cr00021a001
  2. Cueto, M., Jensen, P. R, Kauffman, C, Fenical, W., Lobkovsky, E. and Clardy, J. (2001) Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge. J. Nat. Prod., 64(11): 1444-1446 and references therein https://doi.org/10.1021/np0102713
  3. Andersen, R .J. and Williams, D. E. (2000) Pharmaceuticals from the sea. In Hester, R. E. and Harrison, R .M. (ed.), Chemistry in the marine environment, pp. 55-79, Royal Society of Chemistry: Cambridge, UK
  4. Li, Y., Li, X. E, Kim, D. S.,-Choi, H. D. and Son, B. W. (2003) Indolyl alkaloid derivatives$N_b$,-acetyltryptamine and oxaline from a marine-derived fungus. Arch Pharm. Res., 26(1): 21-23 https://doi.org/10.1007/BF03179925
  5. 한국화학연구소(1989) 신규 의약품 스크리닝 기술개발에 관한연구, pp 153-195, 과학기술처, 서울, 한국
  6. Tubaki, K. (1992) Marine Microorganism as Drug Resources. In Yajirna, H., Shioiri, T., and Ohizumi, Y. (ed.), Marine Resources for Drug Discovery, pp. 313-334. Hirokawa Publishing Co. Tokyo, Japan.