Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Protective Effect of MeOH Extract of Evodia officinalis on Cyanide-induced Neurotoxicity in Cultured Neuroblastoma Cells

오수유 MeOH 추출물이 Cyanide에 의한 신경세포의 보호효과에 미치는 영향

  • Kim, Sang-Tae (Juam of Research Institute Bioscience & Biotechnology,College of Forest Science, Kookmin University) ;
  • Ahn, Soung-Hee (Juam of Research Institute Bioscience & Biotechnology,College of Forest Science, Kookmin University) ;
  • Kim, Jeong-Do (Juam of Research Institute Bioscience & Biotechnology,College of Forest Science, Kookmin University) ;
  • Kim, Young-Kyoon (Juam of Research Institute Bioscience & Biotechnology,College of Forest Science, Kookmin University)
  • 김상태 (주암생명공학연구소,국민대학교 삼림과학대학) ;
  • 안승희 (주암생명공학연구소,국민대학교 삼림과학대학) ;
  • 김정도 (주암생명공학연구소,국민대학교 삼림과학대학) ;
  • 김영균 (주암생명공학연구소,국민대학교 삼림과학대학)
  • Published : 2003.12.30
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Abstract

We reported that neurotoxicity may contribute to cyanide-induced neuronal injury. Cyanide stimulates the release of glutamate which can activate glutamate receptors to propagate excitotoxic processes. We examined the role of plant extracts in mediating the cyanide-induced cytotoxicity and report here that the cytotoxicity assessed in SK- N-SH cell cultures by measuring lactate dehydrogenase (LDH) in the culture media was significantly blocked by Evodia officinalis MeOH extract (OMU). Also, when OMU was treated in NaCN level cultures, the neurite outgrowth was regenerated as much as in the treatment of NaCN only. These results indicate that OMU treatment were not only protected the neurons against NaCN-induced damage but also regenerated the neurite outgrowth of neuroblastoma cells.

Keywords

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