Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antioxidative Activities of Korean Medicinal Plants

한국산 약용식물의 항산화 효과

  • Published : 2003.06.30
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Abstract

One hundred sixty species among Korean medicinal plants were tested on their antioxidative potentials. Antioxidants are useful materials which could be expected into development as food preservatives, health foods, cosmetics and drugs. Korean peninsula have many potential in antioxidant source which includes various medicinal herbs. It grounded on the fact that Korean medicinal plants have been used as folk therapy for long time and still do in oriental medicine. From the study, effective free radical scavengers compared with ${\alpha}-tocopherol\;of\;13.5{\mu}g/ml\;in\;RC_{50}$ were Geranium sibiricum, Geum japonicum, Geranium nepalense subsp. thunbergii and Paulownia coreana which showed $19.3{\mu}g/ml,\;22.5{\mu}g/ml,\;23.9{\mu}g/ml,\;and\;27.2{\mu}g/ml$, respectively, Acer mono and 38 plants showed strong potential in inhibition rate on linoleic acid oxidation (above 90%). In conclusion, we expect that the selected medicinal plants must be more studied as antioxidant and then developed as many industrial materials.

천연 보존제, 기능성 식품 및 화장품 그리고 의약품 신소재의 발굴을 위한 전단계로서 국내산 약용식물 160종 209점에 대한 DPPH 라디칼 소거 및 linoleic acid 과산화 저해 등의 항산화능을 평가하였다. DPPH 라디칼 소거능에서는 $13.5{\mu}g/ml$의 $RC_{50}$을 보인 ${\alpha}-tocopherol$을 대조구로 하였을 때 쥐손이풀 지상부, 뱀무 지상부, 이질풀 지상부, 오동나무 잎이 각각 $19.3{\mu}g/ml,\;22.5{\mu}g/ml,\;23.9{\mu}g/ml,$ 및 $27.2{\mu}g/ml$로서 우수하였고, linoleic acid과산화 반응에 대해서는 고로쇠나무 잎 등 38점의 식물추출물이 90%이상의 강한 항산화력을 나타내었다.

Keywords

References

  1. Blois MS (1958) Antioxidant determinations by the use of a stable free radical. Nature 26 : 199 https://doi.org/10.1038/026199a0
  2. Cho JY, Moon JH and Park KH (2000) Isolation and identification of 3-methoxy-4-hydroxybenzoic acid and 3-methoxy-4-hydroxycinnamic acid from hot water extracts of Hovenia dulcis Thunb and confirmation of their antioxidati ve and antimicrobial activity. Korean J. Food Sci. Technol. 32 : 1403-1408
  3. Choe SY and Yang KH (1982) Toxicological studies of antioxidants, butylated hydroxy toluene (BHT), and butylated hydroxy anisole (BHA). Korean J. Food Sci. Technol, 14 : 283-288
  4. Cook NC and Samman S (1996) Flavonoids-rchernistry, metabolism, cardiovascular effects and dietary sources. Nutritional Biochemistry 7 : 66-76 https://doi.org/10.1016/0955-2863(95)00168-9
  5. Farag RS, Badei AZMA, Hewedi FM and El-Barotv GSA (1989) Antioxidant activity of some spice essential oils on linoleic acid oxidation in aqueous media. JAOCS 66 : 792-799 https://doi.org/10.1007/BF02653670
  6. Frei B (1994) Natural antioxidants in human health and disease. Academic Press. San Diego. 40-55
  7. Haraguchi H, Hashimoto K and Yagi A (1992) Antioxidative substances in leaves of Polygonutn hydropiper. J. Agric. Food Chem. 40 : 1349-1351 https://doi.org/10.1021/jf00020a011
  8. Koh YR, Yoon SJ and Park JW (1997) Lipid peroxidation product-mediated DNA damage and mutagenicity. J. Biochem. Mol Biol 30 : 188-193
  9. Kwon MN, Choi JS and Byun DS (1993) Effect of flavonoid (+ )-catechin as stabilizer in rat fed fresh and peroxidized fish oil. J. Korean Soc. Food Nutr. 22 : 381-391
  10. Lee SE, Seong NS, Park CG and Seong JS (2002) Screening for antioxidative activity of oriental medicinal plant materials. Korean J. Medicinal Crop Sci. 10 : 171-176
  11. Lim KT. Hu C and Kitts DD (2001) Antioxidant activity of a Rhus vemiciflua Strokes ethanol extract. Food and Chemical Toxicology 39 : 229-237 https://doi.org/10.1016/S0278-6915(00)00135-6
  12. Park JC, Chung SK, Hur JM, Lee JR. Choi MR, Song SH and Choi JW (1997) Effects of the components and extracts of some edibile and medicinal plants on the formation of lipid peroxidation in rat liver homogenate. J. Korean Soc. Food Nutr. 26 : 1159-1163
  13. Park SW, Chung SK and Park JC (2000) Active oxygen scavenging activity of luteolin-7-O-$\beta$-D-g1ucoside isolated from Humulus japonicus. J. Korean Soc. Food Nutr.29 : 106-110
  14. Rim YS, Park YM, Park MS, Kim KY. Kim MJ and Choi YH (2000) Screening of antioxidants and antimicrobial activity in native plants. Korean J. Medicinal Crop Sci. 8 : 342-350
  15. Torel J, Cillard J and Cillard P (1986) Antioxidant activity of flavonoids and reactivity with percxy radical. Phytochemistry 25 : 383-385 https://doi.org/10.1016/S0031-9422(00)85485-0
  16. Ueda J, Saito N and Ozawa T (1996) Detection of free radicals produced from reactions of lipid hydroperoxide model compounds with Cu( II) complexes by ESR spectroscopy. Arch. Biochem. Biophys, 255 : 65-76
  17. Yoobida T, Marl K, Hatano T, Okumttta T, Uehara. I, Komagoe K, Fujita Y and Okuda T (1989) Studies on inhibition mechanism of autoxidation by tannin and flavonoids.V. Radical-scavenging effects of tannins and related polyphenols on 1,1-diphenyl-2-picry1hydrazy1 radical, Chem. Pharm. Bull. 37 : 1919-1921 https://doi.org/10.1248/cpb.37.1919