THE EFFECT OF XYLITOL AND CARBOHYDRATES ON THE REPLICATION OF STREPTOCOCCUS ORALS AND STREPTOCOCCUS SALIVARIUS

자일리톨과 탄수화물이 Streptococcus oralis와 Streptococcus salivarius의 증식에 미치는 영향

  • Yang, Kyu-Ho (Department of Pediatric Dentistry, School of Dentistry and Dental Research Institute, Chonnam National University) ;
  • Han, Su-Ji (Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh)
  • 양규호 (전남대학교 치과대학 소아치과학교실 및 치의학연구소) ;
  • 한수지 (피츠버그대학교 약학대학 약학과 약물유전학 센터)
  • Published : 2003.11.29

Abstract

Xylitol is a 5-carbons carbohydrate, which can be replaced with sucrose for preventing caries. The effect of carbohydrates and their combinations with xylitol was studied for the replication of oral bacteria such as Streptococcus oralis and Streptococcus salivarius. The replication of Streptococcus oralis and Streptococcus salivarius was inhibited according to the increased concentration of xylitol. When Streptococcus oralis was incubated for 8 hours in the media added with lactose or sucrose, the optical density was 0.915 and 1.107, repectively. while being 0.127 and 0.104, respectively in the media combined with xylitol. When Streptococcus salivarius was incubated for 8 hours in the media added with lactose or fructose, the optical density was 1.550 and 0.420, repectively. while being 0.271 and 0.905, respectively in the media combined with xylitol. These results indicated that the replication of Streptococcus oralis and Streptococcus salivarius was changed according to kinds of carbohydrates and combined addition of xylitol.

자일리톨은 탄소 5개가 있는 탄수화물로 치아우식증을 억제할 목적으로 사용되는 자당 대체물이다. 구강내 세균인 Streptococcus oralis와 Streptococcus salivarius의 증식에 미치는 탄수화물 단독 및 자일리톨과의 병합작용을 관찰하여 다음과 같은 결과를 얻었다. 배지의 자일리톨 농도가 증가함에 따라 Streptococcus oralis와 Streptococcus salivarius의 증식이 억제되었다. 액체배지에서 Streptococcus oralis의 배양 8시간 배양액 흡광도는 유당 첨가시 0.915, 자당 첨가시 1.107이었으나, 자일리톨을 병합하면 유당 첨가시 0.127, 자당 첨가시 0.104이었다. 액체배지에서 Streptococcus salivarius의 배양 8시간 배양액 흡광도는 유당 첨가시 1.550, 과당 첨가시 0.420이었으나, 자일리톨을 병합하면 유당 첨가시 0.271, 과당 첨가시 0.905이었다. 이상의 결과는 탄수화물의 종류와 자일리톨과의 병합에 따라 Streptococcus oralis와 Streptococcus salivarius의 증식 정도가 달랐다.

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