A Case of Hemobilia due to Gallbladder Carcinoma

혈액 답즙증을 유발한 담낭암 1예

Ahn, Heok-Soo;Mun, Byoung-Sik;Kim, So-Ri;Lee, Soo-Teik;Lee, Seung-Ok
안혁수;문병식;김소리;이수택;이승옥

  • Published : 20030000

Abstract

Gallbladder carcinoma is an uncommon neoplasm, and hemobilia caused by this disease is rare. We present a case of hemobilia in a patient with gallbladder carcinoma, which was recognized at forward duodenoscopy. A 42-year-old man visited our hospital due to intermmittent right upper quadrant pain. Duodenoscopy revealed blood clots with bile juice around the ampulla of Vater and the second portion of the duodenum. Endoscopic ultrasonography for the gallbladder showed a dumbell-shaped mass with a homogenous internal echogenicity on the body of the gallbladder. MR cholangiography showed a lobulated mass with low-signal intensity in the T1-weighted and T2-weighted images. Subsequently, laparoscopic cholecystectomy with regional lymph node dissection was performed, and adenocarcinoma was confirmed.

담낭암은 드물게 발생하는 악성 질환으로, 혈액 담즙증으로 발현되는 경우의 예는 매우 드물다. 본 증례는 간헐적인 우상복부 동통을 주소로 내원한 42세 남자 환자에서 시행한 상부 위장관 내시경에서 혈액 담즙증 소견이 보여, 이의 원인을 찾기 위해 시행한 내시경 초음파와 자기공명영상에서 용종성 담낭 종괴를 발견하였다. 복강경적 담낭 절제술을 시행하였으며, 절제 조직의 병리 조직 검사에서 담낭선암으로 확진한 바 흥미로운 증례로 생각되어 문헌 고찰과 함께 보고하는 바이다.

Keywords

References

  1. Hsu KL, Ko SF, Chou FF, Sheen-Chen SM, Lee TY. Massive hemobilia. Hepato-Gastroenterology 2002;49:306-310
  2. Green MH, Duell RM, Johnson CD, Jamieson NV. Haemobilia. Br J Surg 2001;88:773-786 https://doi.org/10.1046/j.1365-2168.2001.01756.x
  3. Sherlock S, Dooley J. Diseases of the liver and biliary System. 11th ed. London: Blackwell Science, 2002
  4. 김성택, 강민승, 이 구 등. 혈액 담즙증을 유발한 담낭암 1예. 대한소화기내시경학회지 1999;19(suppl):88S-92S
  5. Sandblom P. Hemorrhage into the biliary tract following trauma: “traumatic hemobilia”. Surgery 1948;24:571-586
  6. Merrell SW, Schneider PD. Hemobilia-Evolution of current diagnosis and treatment. West J Med 1991;155:621-625
  7. Kubota H, Kageoka M, Sugimoto K, et al. A patient with undifferentiated carcinoma of gallbladder presenting with hemobilia. J Gastroenterol 2000;35:63-68 https://doi.org/10.1007/PL00009979
  8. John A, Ramachandran TM, Ashraf S, Nair MS, Devi RS. Carcinoma of gallbladder presenting as hemobilia. Indian J Gastroenterol 1999;18:88-89
  9. Uchiyama K, Aida N, Shibuya T, Tanaka S. Early carcinoma of the gallbladder accompanied by hemobilia: report of a case. Surg Today 1998;28:763-767 https://doi.org/10.1007/BF02484626
  10. Cunningham CC, Zibari GB, Johnston LW. Primary carcinoma of the gallbladder: a review of our experience. J La State Med Soc 2002;154:196-199
  11. Kumar S, Jain A, Jain S. Gallbladder carcinoma: experience of 116 cases. Trop Gastroenterol 2000;21:65-68
  12. Grant EG, Smirniotopoulos JG. Intraluminal gallbladder hematoma: sonographic evidence of hemobilia. J Clin Ultrasound 1983;11:507-509 https://doi.org/10.1002/jcu.1870110912
  13. Krudy AG, Doppman JL, Bissonette MB, Girton M. Hemobilia: computed tomographic diagnosis. Radiology 1983;148:785-789 https://doi.org/10.1148/radiology.148.3.6878701
  14. Czerniak A, Thompson JN, Hemingway AP, et al. Hemobilia. A disease in evolution. Arch Surg 1988;123:718-721 https://doi.org/10.1001/archsurg.1988.01400300064010
  15. Yoshida J, Donahue PE, Nyhus LM. Hemobilia: review of recent experience with a worldwide problem. Am J Gastroenterol 1987;82:448-453
  16. Baker AR, Corlett SK, Cookson JB, Carr-Locke DL. Hemobilia treated by nasobiliary catheterization. Am J Gastroenterol 1987;82:783-785
  17. Kroser J, Rothstein RD, Kochman ML. Endoscopic management of obstructive jaundice caused by hemobilia. Gastrointest Endosc 1996;44:618-619 https://doi.org/10.1016/S0016-5107(96)70023-8
  18. Carpenter CM, Bowers JH, Luers PR, Dixon JA, Miller FJ. Neodynium yttrium aluminium garnet laser treatment of hemobilia via a percutaneous biliary catheter track. Radiology 1983;148:853-854 https://doi.org/10.1148/radiology.148.3.6878710
  19. Bloechle C, Izbicki JR, Rashed MY, et al. Hemobilia: presentation, diagnosis, and management. Am J Gastroenterol 1994;89:1537-1540