The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Effect of Water extract of Leonuri Herba on Vasospasm in a Rat Femoral Artery Model

益母草 물추출물이 흰쥐 大腿動脈의 혈관경련에 미치는 영향

Jung Yong-Bal;Kim Hyung-Hwan;Lee, Song-Deuk;Ahn Duk-Kyun;Shin Hye-Seung;Baek Tae-Hyeun;Choi Ho-Young
정용발;김형환;이송득;안덕균;신혜승;백태현;최호영

  • Published : 20030000

⟨ Previous Next ⟩

Abstract

Objective : In order to study the effect of water extract of Leonuri herba (ELS) on the subarachnoid hemorrhage animal model, the autologous whole blood was applied to the vicinity of the sprague dawley rat right femoral artery. Methods : Following periarterial application of autologous whole blood (PAB) and intraperitoneal injection of ELS (10, 100 and 300 mghg, P.o.), the vasomotor responses to ELS were identified and the histological changes, neovascularized blood vessel were observed. Results : Contractile response to ELS (10, 100 and 300 mg/kg, p.0.) was significantly decreased in the rat femoral arteries of PAB 5 and 7 days. In PAB 5 and 7 days, significantly increased vessel wall thickness and narrowed lumen were observed in comparison with the control group. In the arteries exposed to autologous whole blood for 5 and 7 days, a lot of newly generated capillaries in association with markedly curved blood vessel wall thickness, elastic lamina and irregularly oriented endothelial cells were observed in the periphery of the vessel wall. The number of neovascularized blood vessels were significantly decreased in the periphery of PAB with ELS (10, 100 and 300 mg/kg, p.0.) 5 and 7 days. In VEGF expression, Blood plus ELS (10, 100 and 300 mg/kg, p.0.)-exposed vessel were more weak expression than blood-exposed vessel to vein autologous whole blood for 5 and 7 days. Conclusions : From these results, we concluded that ELS inhibited posthemorrhagic chronic vasospasm and neovascularization in rat femoral artery model.

Keywords

References

  1. Laboratory Investigation v.49 Mechanisms of stenosis after arterial injury Alexander W Clowes;Michael A Reidy;Monica M Clowew
  2. 신경외과학 대한신경외과학회
  3. Stroke v.18 Impairment of endothelium-dependent vasodilation induced by acetylcholine and adenosine thiphosphate following experimental subarachnoid hemorrhage Tadayoshi Nagagomi;Neal F. Kassell;Tomio Sasaki;Shigeru Fujuwara;R. Michael Lehman;James C. Tomer
  4. Neurosurgery v.26 Characterization of contractile responses to endothelin in human cerebral arteries: implications for cerebral vasospasm Stephen M, Papadopoulos MD;Lisa L, Gilbert BA.;R Clinton Webb Ph. D.;Constance J. D'Amato BS.
  5. J Neurosurgery v.72 The role of imflammation in experimental cerebral vasospasm Peterson JW;Kwun BD;Hackett JD;Zervas NT.
  6. Neurosurgery v.19 Serum immunocomplexes in patients with subarachnoid hemorrhage Pelletieri L;Nilsson B;Carlsson CA;Nilsson U.
  7. Nature v.386 Mechanisms of angiogenesis Risau W;Flamme I.
  8. 韓國本草圖鑑 安德均
  9. 韓國植物圖鑑 李永魯
  10. 한약약리학 김호철
  11. 現代中藥藥理學 王本祥(편저)
  12. 中藥藥理學 沈映君(주편)
  13. 本草學 全國韓醫科大學 本草學敎室(共編著)
  14. 神農本草經
  15. 本草綱目 李時珍
  16. 中藥大辭典(완벽본) 신문풍출판공사
  17. American Journal of Chinese Medicine v.9 no.1-4 Clinical Observation on the Uterotonic Effect of I-mu Ts'ao (Leonurus artemisia) Wei Chun Chan;Yuk Chu Wong;Yun Cheung Kong;Yiu To Chun;Hang Tat Chang;Wei Fong Chan
  18. Experientia v.30 Kong, Y.C.;K.H. Ng.
  19. Planta Medica Bd. v.31 Yeung, H.W.;Y.C. Kong;W.P. Lay;K.F. Cheng
  20. 中草藥 v.29 no.10 충울자총뇨화수소뇨수축이체소서자궁적비교 潘思源;常英;魏路雪
  21. Stroke v.16 Cerebral vasospasm following aneurysmal subarachnoid hemorrhage Kassell NF;Sasaki T;Colohan ART;Nazar G.
  22. J Neurosurg. v.46 Ruptured intracranial anurysms. Case morbidity and mortality Post KD;Flamm ES;Goodgold A;Ransohoff J.
  23. Acta Neurochir (Wien) v.41 Timing and indication of surgery for ruptured intracranial aneurysms with regard to cerebral vasospasm Sano K;Saito I.
  24. J Neurosurg. v.67 Regional cerebral blood flow studies in subarachnoid hemorrhage Heilbrun, MP;Olesen J;Lassen NA.
  25. J Neurosurg. v.62 Cerebrovascular reactivity in patients with ruptured intracranial anurysms Voldby B;Enevoldsen EM;Jensen FT.
  26. Cerebrovascular Survey Report Cerbral vasospasm following subarachnoid hemorrhage Sasaki T;Kassell NF;Colohan RT;Nagar GB;McDowell FH;Caplan LR(ed.)
  27. Neurosurgery v.27 A rat femoral artery model for vasospasm Okada T;Harada T;Bark DH;Mayberg MR.
  28. Am J physio. v.258 Mechanisms of contracting action of oxyhemoglobin in isolated monkey and dog cerebral arteries Noboru Toda.
  29. Am J physio. v.260 Constrictor action of oxyhemoglobin in monkey and dog basilar arteries in vivo and in vitro Noboru Toda;Masahisa Kawakami;Kazuhide Yoshida
  30. Handbook of Physiology Architecture of the vessel wall Rhodin J.;Bohr D;Somlyo A;Sparks H(ed.)
  31. Arteriosclerosis v.1 George Lyman Duff Memorial Lecture. Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components Ross R
  32. Lab Invest. v.49 Mechanisms of stenosis after arterial injury Clowes AW;Reidy MA;Clowes MM.
  33. Stroke v.18 Functional arterial changes in chronic cerebrovasospasm in monkeys: an in vitro assessment of the contribution to arterial narrowing Bevan JA;Bevan RD;Frazee JG.
  34. Neurosurg Clin N Am. v.1 Morphologic changes in cerebral arteries after subarachnoid hemorrhage Mayberg MR;Okada T;Bark DH.
  35. Neurosurgery v.1 Cerebral vasospasm with ruptured saccular aneurysm-the clinical manifestations Fisher CM;Roberson GH;Ojemann RG.
  36. Neurosurgery v.6 Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomogrphic scanning Fisher CM;Kistler JP;Davis JM.
  37. J Neurosurg v.67 The effect of timing of clot removal on chronic vasospasm in a primate model Handa Y;Weir BK;Nosko M;Mosewich R;Tsuji T;Grace M.
  38. Int Arch Allergy Appl Immunol. v.93 Selective inhibition by magneshinin, compounds from "Shin-i" (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch Kimura M;Kobayashi S;Luo B;Kimura I.
  39. Biochem Biophys Res Comm. v.181 Angiotensin Ⅱ blocks ATP- Sensitive K+ channels in Porcine coronary artery smooth muscle cells Miyoshi Y;Nakaya Y.
  40. Br J Pharmacol. v.106 Comparative studies on the angiogenic activity of IL-1 and IL-8 in a rat sponge model Hu D-E;Y Hori;Fan T-P D.
  41. J Pharmacol Exp Thera. v.274 The Pharmacological Modulation of Angiogenesis in Chronic Granulomatous Inflammation Paul R Colville-Nash;Chandan AS Alam;Ian Appleton;Joanne R Brown;Michael P Seed;Derek A Willoughby
  42. Lab Invest. v.71 no.2 Paracrine interactions between fibroblasts and endothelial cells in a serem-free coculture model. Modulation of angiogenesis and collagen gel contraction Villaschi S;Nicosia RF.
  43. Arterioscler Thromb Vasc Biol. v.21 no.10 Chronic blockade of endothelin receptors improves ischemia-induced angiogenesis in rat hindlimbs through activation of vascular endothelial growth factor-no pathway Iglarz M;Silvestre JS;Duriez M;Henrion D;Levy BI.