The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Mechanism of Crataegi Fructus extract induced endothelium-dependent vasorelaxation in rabbit carotid artery

山査의 내피세포 의존성 혈관이완효과 기전에 대한 연구

Bae, Myeong-Hyo;Kim Ho-Hyun
배명효;김호현

  • Published : 20030000

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Abstract

Objectives : This study was undertaken to define the effect of Chtaegi Fructus on the norepinephrine-induced arterial contraction and the mechanism of Crutuegi Fructus induced relaxation. Methods : In order to investigate the effect of Crutuegi Fructus on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of Crataegi Fructus- induced relaxation, Cratuegi Fructus extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, Nu-nitro- L-arginine, methylene blue or tetraethylammonium chloride. Results : Crataegi Fructus relax arterial strip with endothelium contracted by norepinephrine. but in the strips without endothelium. Crutuegi Fructus-induced relaxation was significantly inhibited. The endothelium-deIwndent relaxation induced by Crutuegi Fructus was decreased by the pretreatment of N, -nitro-r.-arginine or methylene blue, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. When $Ca^{2+}$ was applicated the strips which were contracted by norepinephrine in a $Ca^{2+}$-free solution, arterial contraction was increased. But pretreatment of Cratuegi Fructus inhibited contractile response to $Ca^{2+}$. Conclusions : We suggest that Chtuegi Fructus may suppress influx of extra-cellular $Ca^{2+}$ through the formation of nitric oxide in the vascular endothelial cells.

Keywords

References

  1. 本草綱目 李時珍
  2. 中藥大辭典 江蘇中醫學院
  3. 본초학 康秉秀;高雲彩;金先熙;盧昇鉉;宋昊埈;辛民敎(외5인)
  4. 臨床本草學 辛民敎
  5. 동의생리학회지 v.15 no.1 위점막 보호효과에 대한 산사의 항산화작용과 SH기의 영향 신흥묵;신동훈;김길훤
  6. 동의생리병리학회지 v.16 no.1 산사의 혈관이완효능과 항산화작용 손창우;채종구;김길훤;신흥묵
  7. 원광대 논문집 v.8 no.1 산사 추출액이 백서의 비만모형에 미치는 영향 고광재;송용선
  8. 한국식품영양과학회지 v.28 no.4 시험관법에 의한 식물 열수추출물의 3-Hydroxy-3-Methylglutaryl CoA Reductase 및 Acyl-CoA:Cholesterol Acyltransferase 활성 저해도 측정 이희자;최명숙
  9. 약학회지 v.42 no.1 Propio nibacterium acnes에 대한 항균효과 검색 최승만;김민주;최영호;안호정;윤여표
  10. 한국식품과학회지 v.30 no.4 식품부패 및 병원미생물에 대한 천연약용식물 추출물의 항균효과 오덕환;함승시;박부길;안철;유진영
  11. Arzneim.-Forsch./Drug Res. v.43 no.II Protective Effect of Crataegus Extract on the Cardiac Mechanical Dysfunction in Isolated Perfused Working Rat Heart Nasa, Y.;Hashizume, H.;Ehsanul Hoque, A.N.;Abiko Y.
  12. 中藥藥理與應用 王浴生;鄧文龍;薛春生
  13. 中草藥學 上海中醫學院
  14. Arterial Hypertension v.5 Gross, F.;Robertson, J. I. S.
  15. Acta Anaesthesiol. Scand. Suppl. v.37 no.99 Therapies for perioperative hypertension: Pharmacodynamic considerations Levi, R.
  16. 東醫寶鑑 許浚
  17. 臟象槪說 盛增秀;王琦
  18. 現代中醫內科學 何紹寄
  19. 中醫內科學 上海中醫學院
  20. 玉揪藥解 黃元御
  21. 中華本草 精選本
  22. 東洋天然藥物原色圖鑑 金在佶;肖培根
  23. 高血壓 趙光勝
  24. Circulation v.72 no.4 Platelets and vascular occlusion, Platelets, endothelium, and vasospasm Vanhoutte, P. M.;Houston., D. S.
  25. Ann. Rev. Physiol. v.48 Modulation of vascular smooth muscle contraction by the endothelium Vanhoutte, P. M.;Rubanyi, G. M.;Miller, V.;M., Houston, D. S.
  26. Br. J. Pharmacol. v.93 Endothelium-dependent hyperpolarization of canine coronary smooth muscle Feletou, M.;Vanhoutte, P. M.
  27. Jpn. J. Physiol. v.42 no.2 Nitroarginine-sensitive and -insensitive components of the endothelium-dependent relaxation in the guinea-pig carotid artery Suzuki, H.;Chen, G.;Yamamoto, Y.;Miwa, K.
  28. J. of Cardiovascular Pharmacology v.25 Different Involvement of Nitro Oxide in Endothelium-Dependent Relaxation of Porcine Pulmonary Artery and Vein:Influence of Hypoxia Feletou, M.;Girard, V.;Canet, E.
  29. News Physiol. Sci. v.15 Endothelium-derived hyperpolarzing factor-fact or fiction? Hecker, M.
  30. Br. J. Pharmacol. v.113 Endothelium-derived relaxing factor releaved by 5-HT:distinct from nitric oxide in basilar arteries of normotensive and hypertensive rats Yokota, Y.;Imaizumi, Y.;Ansano, M.;Matsuda, T.;Watanabe, M.
  31. J. Cardiothorac. Vasc. Anesth. v.5 no.1 Endothelium-derived relaxing factor;Basic review and clinical implications Johns R. A.
  32. Nature v.327 Nitric oxide release accounts for the biological actIvIty of endothelium-derived relaxing factor Palmer, R M. J.;Ferrige, A. G.;Moncada, S.
  33. Biochem. Biophys. Res. Commun. v.153 no.3 L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation Palmer, R. M.;Rees, D. D.;Ashton, D. S.;Moncada, S.
  34. Br. J Pharmacol. v.99 L-NG-nitro arginine(L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in uitro Moore, P. K.;al-Swayeh, O. A.;Chong N. W. S.;Evans R. A.;Gibson A.
  35. Am. J. Physiol. v.263 Endothelial cGMP does not regulate basal release of endothelium-derived relaxing factor In culture Nandor, M.;Una, S. R.;John, D. C.
  36. The J. of Pharmacology and Experimental therapeutics v.237 no.3 Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein:Stimulation by acetylcholine, bradyklinin and arachidonic acid Ignarro, L. J.;Harbison, R. G.;Wood, K. S.;Kadowitz, P. J.
  37. Japan J. Pharmacol. v.58 Effects of L-NG-monomethyl arginine onthe cyclic GMP formations in rat mesenteric arteries Noboru, F.; Yoichi, I.;Masayoshi, S.; Yoshiyasu, W.;Masashi, W.;Michinobu, H.
  38. Circulation Research v.52 no.3 Agonist-induced endothelium-dependent relaxation In rat thoracic aorta may be mediated through cGMP Rapoport, R. M.;Murad, F.
  39. Pflugers Arch. v.348 no.1 Relative contributions of Ca influx and cellular Ca release during drug induced activation of the rabbit aorta Deth, R.;Breemen, C. van.
  40. Annuals New York Academy of Sciences Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cells from adult human, dog, cat, rabbit, rat, and frog hearts and from fetal and new-born rat ventricles Fabiato, A.;Fabiato, F.