The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Antioxidative effects of Bojungikgi-tang and Yukmijiwhang-tang in the Liver of senescence-accelerated mouse(SAM)

補中益氣湯과 六味地黃湯이 노화촉진생쥐(SAM)의 간장내 항산화작용에 미치는 영향

Park, Seong-Min;Im, Myeong-Hyeon;Lee, Jun-Hui;Park, Jae-Hyeon
박성민;임명현;이준희;박재현

  • Published : 20030000

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Abstract

Objective: The free radical is a well-known and recent theory of aging. In this theory the oxygen radicals injury and lipid peroxidation are msjor causes of the disease and aging process. Bojungikgi-tang and Yukmijiwhg-k7ng, the prescriptions of oriental medicine, consist of some medicinal herbs. These are generally used for the treatment of aging-related diseases in old man. The effects of Bojungikgktung and Yukmuiwhg-tang were supposed to posses antioxidative activity Method: Bojungikgi-tmg and Yukmjiiwhang-tang in aging, FAP, CD and the activities of antioxidant enzymes in liver were measured on SAM P-1 and R-1 in 4, 12, 24 and 40 weeks of age. Result: BojungikghWag and Yukmuiwhrurg-tang did not change FAP intensity but reduced CD intensity in 40 weeks of age, and increased significantly the activities of glutathione pwoxidase, glutathione reductase, glutathione S-transferase, catalase and superoxide dismutase of SAM P-1 in old weeks of age. Conclustions: Bojungikgi-i-tang and Yukmuiwha,ng-tang play a significant role in the antioxidative reaction and protecting of lipid peroxidation associated with aging.

Keywords

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