The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Effects of Radix Polygalae Extract on Sociopsychological Stress

遠志 추출물이 사회 심리적 스트레스에 미치는 영향

Kim Kyung-Ho;Jeong Hyun-Woo;Lee, Dong-Won;Kim Jeong-Sook;Kim Young-Gyun;Cho Su-In
김경호;정현우;이동원;김정숙;김영균;조수인

  • Published : 20030000

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Abstract

Objectives : The effects of Radix Polygalae extract were tested for the anti-sociopsychological stress action. Methods : 100g of crude drug of Radix Polygalae was extracted with pure water and the total extractive was evaporated under reduced pressure to give 17.0g. ICR male mice(20${\pm}$2g) were fed orally with the dose of 100mg/kg/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : Radix Polygalae extract administered group showed a significant decrease of serum corticosterone secretion compared with control group. Noradrenaline secretions in the dorsal cortex of brain showed no change. Lipid peroxidation and cytotoxicity of the liver of mice were tested by measuring malondialdehyde and serum level of aspartate amintransferase(ALT), and Radix Polygalae extract admistration decreased serum level of ALT. Serum level of malondialdehyde did not changed either. Conclusion : Above results suggest that Radix Polygalae extract can effectively rid the sociopsychological stress.

Keywords

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