The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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A Study on the Effects of Spatholubus suberectus Dunn on the Inhibition of Arthritis Induced by Collagen on the Mouse

鷄血藤이 collagen으로 誘發된 생쥐의 關節炎抑制에 關한 硏究

Choi Jung-Sik;Song, Tae-Won;Kim Dong-Hee
최정식;송태원;김동희

  • Published : 20030000

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Abstract

Objectives : This study was carried out to know the effects of Spatholubus suberectus Durn(hereinafter referred to STSD) on the inhibition of arthritis induced by collagen on the mice. Methods : Various experimental such as arthritis index, incidence, the production of IgM, IgG3. IgG2b, IL-10 and TNF-${\alpha}$, the expression of $CD25^+$, $CD8^+$, $CD69^+$, $NK^+$ and the formation of new bones and synivium were performed in DBA/lJ(mice which are experimental model of arthritis induced by collagen) to analyse the inhibition effects of STSD. Results : The arthritis index, incidence, the production of IgM, IgG3, IgG2b and the production of TNF-${\alpha}$ were decreased. Whereas the production of ll-10 and the expression of $CD25^+$, $CD8^+$, $CD69^+$, $NK^+$ in peripheral blood mononuclear were increased. And also the formation of new bones and synivium were stimulated. Conclusions : Comparison of the results for this study showed that STSD had immunomodulatory effects of suppressing or enhancing. So we expect that STSD should be used as a effective drugs for rheumatoid arthritis. Therefore we have to survey continuously in looking for the effective substance and mechanism in the future.

Keywords

References

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