Effects of Soyosan on Immune Response after Immobilization Stress in Mice

逍遙散이 생쥐에 Immobilization Stress 負荷 後 血中 免疫能系에 미치는 影響

Hong, Sung-Eun;Park, Jong-Moon;Park, Kyung-Mi;Cho, Han-Baek;Yoo, Sim-Keun
홍성은;박종문;박경미;조한백;유심근

  • Published : 20030000

Abstract

The purpose of this research was to investigate the effects of Soyosan water extract (SYS) on immobilization stress in C57BL/6 mice. SYS decreased the serum level of histamine and corticosterone increased by immobilization stress. In addition, SYS enhanced the cell viability of thymocytes and splenocytes decreased by immobilization stress. Also, SYS decreased DNA fragmentation of thymocytes and splenocytes increased by immobilization stress. SYS decreased the population of thymic $CD4^+$ cells and $CD8^+$ cells increased by immobolization stress, and increased the population of $B220^+$ cells decreased by immobilization stress and decreased the population of $Thy1^+$ cells increased by immobilization stress. SYS enhanced the production of ${\gamma}$ -interferon and IL-2 decreased by immobilization stress. Also, SYS enhanced the phagocytic activity decreased by immobilization stress and enhanced the level of nitric oxde decreased by immobilization stress. These results indicate that SYS may be useful for the prevention and treatment of stress via suppression of serum histamine and corticosterone level and enhancement of immune response.

Keywords

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