Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
권호 표지

The Effects of Chungyeulsaseip-tang(Qingrexieshi-tang) on Anti-inflammatory, Analgesic and Anti-febrile Activities on the Arthritis

淸熱瀉顯湯이 관절염의 소염, 진통 및 해열작용에 미치는 영향

Han, Eul-Ju;Lee, Myeong-Jong
한을주;이명종

  • Published : 20030000

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Abstract

Objectives : This study was carried out to examine the effects of Chungyeulsaseip-tang(Qingrexieshi-tang) on anti-inflammatory, analgesic and anti-febrite on the arthritis. Methods and Materials : Each of the 8 rats were classiffied into normal, sample groups in the experiments about anti-inflammatory an anti-febrile. Each of the 8 rats were classiffied into normal, sample groups in the experiments about analgesic. Chungyeulsaseip-tang(Qingrexieshi-tang) was administered to sample group and nomal saline was administered to normal and control groups. Arthritis was induced by injection of 1% carrageenan 0.1$m\ell$and Chungyeulsaseip-tang(Qingrexieshi-tang) was administerd after 30 minutes. WBC, ESR and CRP were measured by heart puncture an NO in urine was measured in 24 hours urine. Synovium of rat's knee was measured by heart puncture an NO in urine was measured in 24 hours urine. Synovium of rat's knee was cultured with carrageenan and Dulbico's modified Eagle's medium and re-cultured with 2% Chungyeulsaseip-tang(Qingrexieshi-tang) for 72 hours and NO in synoviocytes was measured. Writhing syndroma was measured by Whittle's method in the experiments about analgesic. Rectal temprature was measured by Yeast's method in the experiments about anti-febrile. Conclusions : 1. It was recognized that Chungyeulsaseip-tang(Qingrexieshi-tang) has and anti inflammatory effect in. 2. It was recognized that Chungyeulsaseip-tang(Qingrexieshi-tang) effetively analgesic function on the artificial arthritis resulted from carrageenan. According to the above results, it can be concluded Chungyeulsaseip-tang(Qingrexieshi-tang) showed the treatment effects on the artificial arthritis resulted from carageenan in rats and mice and it is suggested that more interest and study in the security for the clinical use were needed.

Keywords

References

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