Yonsei Medical Journal

Yonsei Univ College Medicine (연세대학교의과대학)
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Dopamine Transporter Genotype Influences the Attention Deficit in Korean Boys with ADHD

Oh, Kang-Seob;Shin, Dong-Won;Oh, Guk-Taek;Noh, Kyung-Sun

  • Published : 20031000

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Abstract

Attention appears to be inheritable, stable and influenced by genetic factors. The use of the Continuous Performance Test (CPT), as an endophenotypic measure, is valuable for genetic studies because it may show increased sensitivity to specific dimensions in attention deficit hyperactivity disorder. However, few studies have been designed to examine the influence of the genotype on attention level measured by CPT in ADHD patients. This study examinee the difference between 10/10 and $10/^{*}$ genotype in the attention deficits measured by the CPT in ADHD patients. Forty-four unrelated ADHD patients were recruited from the psychiatric outpatients' clinic at Kangbuk Samsung Hospital. Two child psychiatrists made the diagnoses of ADHD using the DSM- IV diagnostic criteria. The genomic DNA was extracted from the blood, and analyzed to determine the genotype. A 40- base pair variable number of tandem repeats (VNTR) polymorphism in the 3' untranslated region was amplified. The attention deficits were measured by the test of variables of attention (T.O.V.A.). Between the 10/10 genotype and $10/^{*}$ genotype, standard scores of the T.O.V.A were compared using a Mann-Whiney test. A comparison with the 10/10 genotype and $10/^{*}$ genotype showed that those patients with the 10/10 genotype made less omission errors in the first quarter of the test (p < 0.05, by Mann-Whiney test). No significant differences were observed in the errors of commission, response time, variability. This study found that the 10/10 genotype made less omission errors on the T.O.V.A. This suggests that the dopamine transporter genotype influences the attention deficits measured by T.O.V.A.

Keywords

References

  1. Diagnostic and statistical manual of mental disorders American Psychiatric Association
  2. Attention deficit hyperactivity disorder. A handbook for diagnosis and treatment Barkley, R.A.
  3. Child Adolesc Psychiatr Clin North Am v.10 The nature and heritability of attention-deficit/hyperactivity Disorder Faraone, S.V.;Doyle, A.E.
  4. Curr Psychiatry Rep v.3 Genes and attention deficit hyperactivity disorder Swanson, J.;Posner, M.;Fusella, J.;Wasdell, M.;Sommer, T.;Fan, J.
  5. J Am Acad Child Adolesc Psychiatry v.36 Attention-deficit hyperactivity disorder dimensions: a twin study of inattention and impulsivity-hyperactivity Sherman, D.K.;Iacono, W.G.;McGue, M.
  6. Psychiatr Clin North Am v.15 Pharmacologic treatment of attention deficit hyperactivity disorder Greenhill, L.L.
  7. Psychiatry Res v.36 Methylphenidate and dextroamphetamine treatments of hyperactivity: are there true nonresponders? Elia, J.;Borcherding, B.G.;Rapoport, J.L.;Keysor, C.S.
  8. Psychopharmacol Bull v.23 A double-blind trial of bupropion in children with attention deficit disorder Casat, C.;Pleasant, D.;Fleet, J.
  9. J Am Acad Child Adolesc Psychiatry v.33 Attention deficit disorder and methylphenidate: normalization rates, clinical effectiveness and response prediction in 76 children Rapport, M.;Denney, C.;DuPaul, G.;Gardner, M.
  10. Nature v.379 Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter Giros, B.;Jaber, M.;Jones, S.R.;Wightman, R.M.;Caron, M.G.
  11. Proc Natl Acad Sci v.95 Profound neuronal plasticity in response to inactivation of the dopamine transporter Jones, S.R.;Gainetdinov, R.R.;Jaber, M.;Giros, B.;Wightman, R.M.;Caron, M.G.
  12. Biol Psychiatry v.46 Functional hyperdopaminergia in dopamine transporter knock-out mice Gainetdinov, R.R.;Jones, S.R.;Caron, M.G.
  13. Behav Pharmacol v.11 Behavioural disturbances associated with hyperdopaminergia in dopamine-transoprter knockout mice Spielewoy, C.;Roubert, C.;Hamon, M.;Nosten-Bertrand, M.;Betancur, C.;Giros, B.
  14. Mol Brain Res v.15 A human dopamine transporter cDNA predicts reduced glycosylation, displasys a novel repetitive element and provides racially-dimorphic TaqI RFLPs Vandenbergh, D.J.;Persico, A.M.;Uhl, G.R.
  15. Hum Biol v.72 Distribution of the 3' VNTR polymorphisom in the human dopamine transporter gene in world populations Mitchelle, R.J.;Howlett, S.;Earl, L.;White, N.G.;McComb, J.;Schanfield, M.S.(et al.)
  16. Hum Hered v.45 Amplification of DATI (human dopamine transporter gene)3' variable region in the Japanese population Nakatome, M.;Honda, K.;Islam, M.N.;Terada, M.;Yamazaki, M.;Kuroki, H.(et al.)
  17. Hum Biol v.68 Genetic polymorphism of the 3' VNTR region of the human dopaminergic function gene DATI (human dopamine trasporter gene) in the Mongolian population Nakatome, M.;Honda, K.;Tun, Z.;Kato, Y.;Harihara, S.;Omoto, K.(et al.)
  18. J Korean Neuropsychiatr Assoc v.41 Association between attention deficit hyperactivity disorder and dopamine transporter gene (DAT1) polymorphism in Korean Shin, D.W.;Noh, K.S.;Oh, K.S.;Lee, M.S.
  19. Am J Hum Genet v.56 Association of attention-deficit disorder and dopamine transporter gene Cook, E.H.;Stein, M.A.;Krasowski, M.D.;Cox, N.J.;Deborah, M.O.;Kieffer, J.E.(et al.)
  20. Mol Psychiatry v.1 Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder LA Hoste, G.J.;Swanson, J.M.;Wigal, S.B.;Glabe, C.;Wigal, T.;King, N.(et al.)
  21. Mol Psychiatry v.2 Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism Gill, M.;Daly, G.;Heron, S.;Hawi, Z.;Fitgerald, M.
  22. Am J Hum Genet v.63 Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity Waldman, I.D.;Rowe, D.C.;Abramowitz, A.;Kozel, S.T.;Mohr, J.H.;Sherman, S.L.(et al.)
  23. Mol Psychiatry v.6 Association study of a dopamine transporter polymorphism and attention deficit UK and Turkish samples Curran, S.;Mill, J.;Tahir, E.;Kent, L.;Richards, S.;Gould, A.(et al.)
  24. Mol Psychiatry v.5 A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder Holmes, J.;Payton, A.;Barrett, J.H.;Hever, T.;Fitzpatrick, H.;Trumper, A.L.(et al.)
  25. Am J Med Genet v.105 Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene Roman, T.;Schmitz, M.;Polanczk, G.;Eizirik, M.;Rohde, L.A.;Hutz, M.H.
  26. Am J Med Genet v.114 Dopamine transporter polymorphism associated with externalizing behavior problems in children Young, S.E.;Smolen, A.;Corley, R.P.;Krauter, K.S.;DeFries, J.C.;Crowley, T.J.(et al.)
  27. BMC Neurosci v.2 Assessing the heritability of attentional networks Fan, J.;Wu, Y.;Fosa, J.A.;Posner, M.I.
  28. Psychiatr Res v.26 The Continuous Performance Test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families Cornblatt, B.A.;Risch, N.J.;Faris, G.;Friedman, D.;Erlenmeyer-Kimling, L.
  29. BMC Neurosci v.3 Assessing the molecular genetics of attention networks Fossella, J.;Sommer, T.;Fan, J.;Wu, Y.;Swanson, J.M.;Pfaff, D.W.(et al.)
  30. T.O.V.A. TM interpretation manual Greenberg, L.M.
  31. J Am Acad Child Adolesc Psychiatry v.36 Attention-deficit hyperactivity disorder: a category or a continuum? genetic analysis of a large-scale twin study Levy, F.;Hay, D.A.;McStephen, M.;Wood, C.;Waldman, I.
  32. Behav Genet v.22 Evidence for a genetic etiology in hyperactivity in children Stevenson, J.
  33. Mol Psychiatry v.7 Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression Miller, G.M.;Madras, B.K.
  34. Am J Med Genet v.114 Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR Mill, J.;Asherson, P.;Browes, C.;D'Souza, U.;Craig, I.
  35. Pharmacogenomics J v.1 The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression Fuke, S.;Suo, S.;Takahashi, N.;Koike, H.;Sasagawa, N.;Ishiura, S.
  36. Neuropsychopharmacology v.22 Genotype influences in vivo dopamine transporter availability in human striatum Heinz, A.;Goldman, C.;Jones, D.W.;Palmour, R.;Hommer, D.;Gorey, J.G.(et al.)
  37. Am J Psychiatry v.157 Prediction of dopamine transporter binding availability by genotype: a preliminary report Jacobsen, L.;Staley, J.;Zoghbi, S.S.;Seibyl, J.P.;Kosten, T.R.;Innis, R.B.(et al.)
  38. Am J Med Genet v.97 Sustained attenion deficits as markers of genetic susceptibility to Schizophrenia Chen, W.J.;Faraone, S.V.
  39. Am J Med Genet v.105 Impaired attention as an endophenotype for molecular genetic studies of schizophrenia Cornblatt, B.A.;Malhotra, A.K.
  40. Mol Psychiatry v.6 Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms Rowe, D.C.;Stever, C.;Chase, D.;Sherman, S.;Abramowitz, A.;Waldman, I.D.
  41. Annu Rev Neurosci v.13 The attention system of the human brain Posner, M.I.;Petersen, S.E.