Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
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Differential Expression of Hypoxia Inducible $Factor-1{\alpha}$ and Tumor Cell Proliferation Between Squamous Cell Carcinomas and Adenocarcinomas Among Operable Non-Small Cell Lung Carcinomas

Lee, Chang-Hun;Lee, Min-Ki;Kang, Chi-Duk;Kim, Young-Dae;Park, Do-Youn;Kim, Jee-Yeon;Sol, Mee-Young;Suh, Kang-Suek

  • Published : 20030400

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Abstract

This study aimed to evaluate whether the elevated level of hypoxia-inducible $Factor-1{\alpha}\;(HIF-1{\alpha})$ correlated with histologic types, angiogenesis, tumor cell proliferation, and clinical parameters in common non-small cell lung carcinomas (NSCLCs). We performed immunohistochemical stains using paraffin-embedded tissue blocks from 84 cases of operable NSCLC [No. of squamous cell carcinoma (SCC), 45; No. of adenocarcinoma (AC), 39]. $HIF-1{\alpha}$ expression was related with histologic types (66.7% in SCCs vs 20.5% in ACs, p<0.001), but not with lymph node status, tumor stage, vascular endothelial growth factor expression, microvessel density (MVD), and proliferating cell nuclear antigen (PCNA) index (p>0.05, respectively). As for the histologic types, MVD and PCNA index were significantly higher in SCCs than in ACs (p=0.009 and p=0.016, respectively). Among $HIF-1{\alpha}$ positive carcinomas, MVD was significantly higher in $HIF-1{\alpha}$ positive SCCs than in $HIF-1{\alpha}$ positive ACs (p=0.023). The overall survival curves were not associated with $HIF-1{\alpha}$ expression or any other histologic parameters (p>0.05). These findings suggest that $HIF-1{\alpha}$ expression in NSCLCs may play a differential role according to histologic types, but its prognostic significance is indeterminate.

Keywords

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