The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Mori Cortex Decreases the Acute Edematous Lung Injury Induced by Skin Burn

피부화상으로 유도된 급성 부종성 폐손상에 대한 상백피의 효능

Jo Hyun-Gug;Lee Young-Man;Kang Byung-Soo;Jeune Kyung-Hee;Park Won-Hark
조현국;이영만;강병수;전경희;박원학

  • Published : 20030000

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Abstract

Objectives : The present study was conducted to determine whether administration of heat extracts of blori Cortex has an inhibitory effect of neutrophil-derived oxidative injury following dermal scald bum in rats. Methods : Acute lung injury was induced by scald bum (15% of TBSA) in rats. To identify acute lung edematous lung injury, 5 hrs after skin bum, protein concentrations and the number of polymorphonuclear leukocytes in bronchoalveolar lavage (BAL) were measured. In addition, levels of lung KC (neutrophil chemoattractant cytokine) and activities of lung myeloperoxidase (MPO) were measured, and morphological changes were observed. Results : Lung weight and concentration of BAL protein, the index of lung injury, were clearly increased at 5 hrs postbum compared to them of sham. Administration of heat extracts of Mori Cortex after scald burn inhibited the prtduction of KC in lung tissue and decreased the activity of lung MPO as a result of neutrophil infiltration. In histological changes, edematous lung injury with infiltration of inflammatory cells induced by skin bum were decreased by administration of heat extracts of Mori Cortex after scald bum. Conclusions : These results suggest that Mori Cortex may be a successful medical stuff in acute lung injury induced by skin bum.

Keywords

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