Korean journal of dermatology (대한피부과학회지)

Korean Dermatological Association (대한피부과학회)
권호 표지

Clinical and Histopathological Study of Cutaneous Melanoma in Korea

한국인에서의 악성 흑색종에 대한 임상 및 병리 조직학적 연구

Lee, Mi-Woo;Koh, Jai-Kyoung;Kwon, Kyung-Sool;Kim, Nack-In;Kim, Sang-Won;Kim, Soo-Nam;Kim, Bang-Soon;Kim, You-Chan;Kim, Jong-Min;Myung, Ki-Bum;Park, Jang-Kyu;Suh, Kee-Suck;Son, Sook-Ja;Song, Eun-Sup;Cho, Kwang-Hyun;Cho, Baik-Kee;Oh, Chee-Won;Won, Young-Ho;Yoon, Tae-Young;Lee, Kyu-Suk;Lee, Seok-Jong;Lee, Young-Suk;Lee, Won-Soo;Lee, Eil-Soo;Ihm, Chull-Wan;Jang, Kyoung-Ae;Chang, Sung-Nam;Hahm, Jeong-Hee
이미우;고재경;권경술;김낙인;김상원;김수남;김방순;김유찬;김종민;명기범;박장규;서기석;손숙자;송은섭;조광현;조백기;오지원;원영호;윤태영;이규석;이석종;이용석;이원수;이일수;임철완;장경애;장성남;함정희

  • Published : 20030100
⟨ Previous Next ⟩

Abstract

Background : Malignant melanoma in Korea has been increasing as in other countries, but there is no nationwide survey of malignant melanoma in Korea. Objective : The aim of this study was to document the clinical and histopathological features of cutaneous melanoma in Korea. Methods : The Dermatopathology Research Group conducted a review of nationwide collection of 109 primary cutaneous melanomas, diagnosed at 23 institutes over a recent 3-year period. Clinical records and pathology slides of the patients were reviewed retrospectively. Results and Conclusion : 1. The peak age was the 7th decade with the mean age of 58.1 years. Korea has a higher rate of acral melanoma and much lower rate of lentigo maligna melanoma. 2. Major component tumor cell was spindle cell type. 3. Clark level of tumor was III or more and Breslow depth was 2mm or more at the time of the first diagnosis in many cases (62%). 4. Pre-existing melanocytic nevus was present in a few cases (3 cases). 5. All these features suggest that the racial difference between the Korean and the Caucasian is evident. We also suggest that an early detection program is very important to cure this malignant tumor. (Korean J Dermatol 2003;41(1) : 43-47)

Keywords

References

  1. 문상은，조광현，황지환，김정애，윤재일. 피부 악성 종양의 통계적 고찰(1990년-1995년) 대피지 1998;36:7-15
  2. 조광현，이유신. 피부 악성 종양의 임상적 관찰. 대피지 1984;22:394-403
  3. 정진호，조광현，장승호，김규한，이유신，함의근 등. 피부 악성 종양의 통계적 고찰. 대한의학협회지 1991; 34:57-68
  4. Kuchelmeister C, Schaumburg-Lever G, Gabre C. Acral cutaneous melanoma in Caucasian: clinical features, histopathology and prognosis in 112 patients. Br J Dermatol 2000; 143:275-280 https://doi.org/10.1046/j.1365-2133.2000.03651.x
  5. Reintgen DS, McCarty KM, Cox E, Seigler HF. Malignant melanoma in black American and white American populations. A comparative review. JAMA 1982;248:1856-1859
  6. Kukita A, Ishihara K. Clinical features and distribution of malignant melanoma and pigmented nevi on the sole of the feet in Japan. J Invest Dermatol 1989;92:210-213 https://doi.org/10.1111/1523-1747.ep12276738
  7. Collins RJ. Melanoma in the Chinese of Hong Kong. Cancer 1984;54' 1482-1488 https://doi.org/10.1002/1097-0142(19841001)54:7<1482::AID-CNCR2820540745>3.0.CO;2-O
  8. 조광현. 피부의 악성 흑색종 대한의학협회지 1990;33: 625-631
  9. 원영호，허수경，이승철，전인기，김영표. 최근 10년간 악성 흑색종의 임상 및 병리조직학적 연구. 대피지 1991;29:193-202
  10. 송계용，정경천，조광현，지제근，함의근. 악성 흑색종의 임상 및 병리조직학적 고찰. 대한병리학회지 1997; 31:566-573
  11. Kato T, Suetake T, Sugiyama Y, Tabata N, Tagami H. Epidemiology and probnosis of subungual melanoma in 34 Japanese patients. Br J Dermato1 1996;134:383-387 https://doi.org/10.1111/j.1365-2133.1996.tb16218.x
  12. Takematsu H, Obata M, Tomita Y, Kato T, Takahashi M, Abe R. Subungual melanoma. A clinicopathologic atudy of 16 Japanese cases. Cancer 1985;55:2725-2731. https://doi.org/10.1002/1097-0142(19850601)55:11<2725::AID-CNCR2820551134>3.0.CO;2-V
  13. 이종희，유종엽，조광현. 손바닥의 멜라닌 세포성 모반에서 발생한 악성 흑색종 l 예. 대피지 2000;39: 1169-1172
  14. Clark WH, Elder DE, Guerry D. A study of tumor progression : the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 1984;15:1147-1165 https://doi.org/10.1016/S0046-8177(84)80310-X
  15. Ackerman AB, David KM. A unifying concept of malignant melanoma : Biologic aspects. Hum Pathol 1986;17: 438-440 https://doi.org/10.1016/S0046-8177(86)80030-2
  16. Sondergaard K, Olsen G. Malignant melanoma of the foot : A clinicopathologic study of 125 primary cutaneous malignant melanomas. Acta Pathol Microbiol Scand Sec A 1980;88:275-283
  17. Kanzler MH, Mraz-Gernhard S. Primary cutaneous malignant melanoma and its precursor lesions : diagnostic and therapeutic overview. J Am Acad Dermatol 2001; 45:260-276 https://doi.org/10.1067/mjd.2001.116239
  18. Sober AJ, Chuang TY, Duvic M, Farmer ER, Grichnik JM, Haipern AC. Guidelines of care for primary cutaneous melanoma. Am Acad Dermatol 2001;45:579-586 https://doi.org/10.1067/mjd.2001.117044
  19. Balch MC, Buzaid CA, Atkins BM, Cascinelli N, Coit GD, Fleming DI et al. A new American joint committee on cancer staging system for cutaneous melanoma. Cancer 2000;88:1484-1491 https://doi.org/10.1002/(SICI)1097-0142(20000315)88:6<1484::AID-CNCR29>3.0.CO;2-D
  20. Department of Health and Human Services, public Health Service. NIH Consensus Development Panel on Early Melanoma: diagnosis and treatment of early melanoma. JAMA 1992;268:1314-1319 https://doi.org/10.1001/jama.268.10.1314
  21. Zitelli JA, Braun CD, Hanusa BH. Surgical margins for excision of primary cutaneous melanomas. J Am Acad Dermatol 1887;37:422-429 https://doi.org/10.1016/S0190-9622(97)70144-0
  22. Balch cm, Soong S, Bartolucci AA. Efficacy of an elsctive regional lymph node dissection of 1 to 4 mm thick melanomas for patients 60 years of age and younger. Ann Surg. 1996;224:255-266. https://doi.org/10.1097/00000658-199609000-00002