Clinical and Molecular Hepatology (대한간학회지)

The Korean Association for the Study of the Liver (대한간학회)
권호 표지

Outbreak of Hepatitis by Odentia tsutsugamushi in the Early Years of the New Millenium

2000년대 초에 유행한 Orientia tsutsugamushi에 의한 간염

Park, Jae-Il;Han, Sung-Hee;Cho, Seung-Chul;Jo, Yong-Hyeon;Hong, Sang-Mo;Lee, Hak-Hynn;Yun, Hye-Ryeon;Yang, Sun-Young;Yoon, Jai-Hoon;Yun, Yeong-Seop;Moon, Ji-Yong;Cho, Kyung-Ran;Baik , Sang-Hyun;Son , Joo-Hyun;Kim, Tae-Wha;lee, Dong-Hoo
박재일;한성희;조승철;조용현;홍상모;이학현;윤혜련;양선영;윤재훈;윤영섭;문지용;조경란;백상현;손주현;김태화;이동후

  • Published : 20030000
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Abstract

Background!Aims: Orieniia-tsutsuqamushi infection is an acute febrile disease due to fhe accidental transmission fhrough human skin of forest dwelling vector Leptccrombidium larva. The authors observed liver dysfunctions in patients diagnosed with tsutsugamushi disease (Scrub typhus) in the past 3 years and report fhe data in the hope of bringing attention to this disease in the differentiai diagnosis of autumn-season hepatitis, especially of non-A, non-B and nori-C hepatitis. Methods: Medical records of 22 patients diagnosed wifh tsutsugamushi disease by the hemagglutinin method between October 2000 and November 2002 were reviewed. Results: Femaie gender was dominant in the ratio of 3.4:1. Mean age was 56.4$\pm$2.6.Admission was between 23rd September and 15th November wifh the peak between mid October and early November. Fever, being the most common symptom, was observed in 21 cases, myalgia in 13, arthralgia in 12, chills in 6, and skin rash in 6. An incubation period of 7-9 days was most common (10 cases), 13-15 days (4), 10-12 days (3), within 3 days (3), and 4-6 days (2). Average ALT, AST and GGTP were increased to 93.2$\pm$17.3 lU/L (18$\pm$345 lU/L), 92.5$\pm$11.7 lU/L (34-255 lU/L) and 132.2$\pm$14.5 lU/L (]9-251 lU/L),respectively, but total bilirubin was normal, All the patients improved with doxycycline therapy, Conclusions: Since it usually shows liver dysfunction, it is important to take Orieniia tsutsugamushi into consideration in differential diagnosis of autumn-season, febrile hepatic disease.

Keywords

References

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