Clinical and Molecular Hepatology (대한간학회지)

The Korean Association for the Study of the Liver (대한간학회)
권호 표지

Assessment of Quality of Life and Associated Factors in Patients with Chronic Viral Liver Disease

만성 바이러스성 간질환 환자의 삶의 질 평가 및 관련인자 분석

Park, Chang-Keun;Park, Soo-Young;Kim, Eun-Soo;Park, Jin-Hyung;Hyun, Dong-Woo;Yun, Young-Mi;Jo, Chang-Min;Tak, Won-Young;Kweon, Young-Oh;Kim, Sung-Kook;Choi, Yong-Hwan;Park, Shin-Goo
박창근;박수영;김은수;박진형;현동우;윤영미;조창민;탁원영;권영오;김성국;최용환;박신구

  • Published : 20030000
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Abstract

Background/Aims: The aim of this study was to measure health related quality of life (HRQOL) in patients with chronic viral hepatitis or cirrhosis and to determine factors associated with more severe impairment Methods: We conducted a cross-sectional study in which we documented patients' demographic and clinical characteristics and measured their HRQOL using the Korean version of Short Form-36. A total of 015 patients were enrolled in the study. We compared patients' HRQOL with that of 750 participants in a control group and assessed the associatim of HRQOL impairment with clinical parameters. Results: In all except two domains (physical functioning, bodily pain) of SF-36, HRQOL scores were significantly lower in the patient group than in the control group (p<0.001 The difference was more prominent in those domains reflective of mental, rather than physical, health. When patient group was classified as noncirrhosis, Child A, B, or C aocording to modified Child-Pugh classification, severe liver disease was associated with a lower HRQOL score. Interestingly, scores of domains reflective of mental health were decreased from the early stage of disease (noncirrhosis or Child-Pugh A). Those of domains reflective of physical health, however, were decreased only in advanced stages of disease (Child-Pugh B or C). There are weak but significant correlations between SF-36 scores and age, serum albumin, serum bilirubin, and prothrombin time, but no correlation with histologic activity, transaminase level, disease duration, virus type (HEV or HCV) and HEV DNA level. Conclusions: Compared with the control group, patients with chronic viral hepatitis or cirrhosis showed substantial impairment of HRQOL, which is further affected by worsening disease severity. More concern about HRQOL should be warranted in the evaluation of health change due to disease progression or therapeutic trial.

Keywords

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