The Korean Journal of Physical Education (한국체육학회지)

Korean Alliance for Health: Physical Education: Recreation:and Dance (한국체육학회)
권호 표지

The Relationship between Fat Distribution and Adipocytokines before and after Combined Exercise in Obese Middle-Aged Women

복합운동전후 중년 비만여성의 지방분포와 Adipocytokines 과의 관계

Park, Jae-Hyun;Kim, Ho-Sung;Park, Jin-Kee;Kwon, Yoo-Chan;Park, Sang-Kab
박재현;김호성;박진기;권유찬;박상갑

  • Published : 20030000
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Abstract

Obesity is an increasingly prevalent nutritional disorder throughout the world and is a risk factor for many chronic diseases. The prevalence of obesity increases with age. Circulating concentrations of adipocytokines, such as leptin, tumor necrosis factor-a(TNF-a), and plasminogen activator inhibitor-1(PAI-1), vary with exercise training, menopause, or regional variations in adipose tissues. In the present study, the relationships between body fat distributions and some adipocytokines were compared in obese middle-aged women, before and after exercise training. Six subjects performed a combined aerobic and resistance exercise training 6 days a week during 10 weeks. Aerobic exercise training composed of 30 minutes a day, at 60% of HRmax. Resistance exercise training composed of 40 minutes a day, at 70% of 1RM. The training reduced body weight, percent body fat, total fat volume(TFV), subcutaneous fat volume(SFV), and leptin and PAI-1 in obese women. Leptin correlated closely with SFV after training. In contrast to Leptin, no significant correlated was found between PAI-1 and any of the fat depots. Thus, our data suggest that changes in Leptin correlated with specific alterations in relative amount of SFV and VFV after training. But body fat distributions could not play a crucial role in the regulation of PAI-1 levels.

Keywords

References

  1. Arner P. (2001). Regional differences in protein production by human adipose tissue. Biochem. Soc. Trans. 29, 72-75
  2. Centers of Disease Control and Prevention and The American College of Sports Medicine. (1995). Physical activity and public health. JAMA, 273, 402-407
  3. Dirlewanger M, Di Vetta V, Giusti V, Schneiter P, Jequier E, Tappy L. (1999). Effect of moderate physical activity on plasma leptin concentration in humans. Eur. J. Appl. Physiol. Occup. Physiol. 79(4), 331-335
  4. Dusserre E, Moulin P, Vidal H. (2000). Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues. Biochim. Biophys. Acta. 1500(1), 88-96
  5. Eriksson P, Van Harmelen V, Hoffstedt J Lundquist P, Vidal H, Stemme V, Hamsten A, Arner P, Reynisdottir S (2000). Regional variation in plasminogen activator inhibitor-1 expression in adipose tissue from obese individuals. Thromb. Haemost. 83(4), 545-548
  6. Giltay EJ, Elbers JM, Gooren LJ, Emeis JJ, Kooistra T, Asscheman H, Stehouwer CD. (1998). Visceral fat accumulation is an important determinant of PAI-l levels in young, nonobese men and women: modulation by cross-sex hormone administration. Arterioscler. Thromb. Vasc. Biol. 18(11). 1716-1722
  7. Hube F, Lietz U, Igel M, Jensen PB. Tornqvist H, Joost HG, Hauner H, (1996). Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans. Horm. Metab. Res. 28(12), 690-693
  8. Janand-Delenne B, Chagnaud C, Raccah D, Alessi MC, Juhan-Vague I, Vague P. (1998). Visceral fat as a main determinant of plasminogen activator inhibitor 1 level in women, Int. J. Obes. Relat. Metab. Disord. 22(4), 312-317
  9. Kiyonga A, Arakawa K, Tanaka H, Shindo M. (1985). Blood pressure and hormonal responses to aerobic exercise. Hvpertension, 72, 125-131
  10. Kuramoto AK, Payne VG. (1995). Predicting muscular strength in women: a preliminary study. Res. Q. Exerc. Sport. 66, 168-172
  11. Matsuzawa Y. (2001). Life style-related disease. Nippon. Rinsho. 59, 188-194
  12. Meier CA. (1996). Leptin secretion and action: an update. Eur. J. Endocrinol. 134, 543-545
  13. Moldoveanu AI, Shephard RJ, Shek PN. (2000). Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells. J. Appl. Physiol. 89(4), 1499- 1504
  14. Montague CT, Prins JB, Sanders L, Zhang J, Sewter CP, Digby J. Byrne CD, O'Rahilly S. (1998). Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes. 47(9), 1384-1391
  15. Pasman WJ, Westerterp-Plantenga MS, Saris WH. (1998). The effect of exercise training on leptin levels in obese males. Am. J. Physiol. 274, 280-286
  16. Pinkney JH, Coppack SW, Mohamed-Ali V. (1998). Effect of isoprenaline on plasma leptin and lipolysis in humans. Clin. Endocrinol. 48(4), 407-411
  17. Schuit AJ, Schouten EG, Kluft C, de Maat M, Menheere PP, Kok FJ. (1997). Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women. Thromb. Haemost. 78(2), 845-851
  18. Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K. Nakamura T, Yamashita S. Miura M, Fukuda Y, Takemura K, Tokunaga K, Matsuzawa Y. (1996). Enhanced expression of PAI-1 in visceral fat: possible obesity. Nat. Med. 2(7), 800- 803
  19. Sinha MK. (1997). Human leptin: the hormone of adipose tissue. Eur. J Endocrinol. 135, 461-464
  20. Thong FS, Hudson R, Ross R, Janssen I, Graham TE. (2000). Plasma leptin in moderately obese men: independent effects of weight loss and aerobic exercise. Am. J. Physiol. Endocrinol. Metab. 279(2), 307-313
  21. Tsukui S, Kanda T, Nara M, Nishino M, Kondo T, Kobayashi I. (2000). Moderate- intensity regular exercise decreases serum tumor necrosis factor-alpha and HbAlc levels in healthy women, Int. J. Obes. Relat. Metab. Disord. 24(9), 1207-1211
  22. van den Burg PJ, Hospers JE, van Vliet M, Mosterd WL, Bouma BN, Huisveld IA. (1997). Effect of endurance training and seasonal fluctuation on coagulation and fibrinolysis in young sedentary men. J, Appl. Physiol. 82(2): 613-620
  23. van Dielen FM, van't Veer C, Schols AM, Soeters PB, Buurman WA, Greve JW. (2001). Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals, Int. J. Obes. Relat. Metab. Disord. 25(12), 1759-1766