Nationwide Study for Epidemiological Change of Atopic Dermatitis in School Aged Children between 1995 and 2000 and Kindergarten Aged Children in 2003 in Korea

1995년과 2000년의 학동기와 2003년 학동전기 소아에서의 아토피피부염의 역학적 변화에 관한 전국적인 연구

O, Jae-Won;Kim, Gyu-Eon;Pyeon, Bok-Yang;Lee, Hye-Ran;Jeong, Ji-Tae;Hong, Su-Jong;Park, Gang-Seo;Lee, Su-Yeong;Song, Sang-Uk;Kim, Cheol-Hong;An, Gang-Mo;Nam, Seung-Yeon;Son, Myeong-Hyeon;Kim, U-Gyeong;Lee, Mi-Hui;Gwon, Byeong-Cheol;Choe, Seong-Yeon;Lee, So-Yeon;Lee, Ha-Baek;Lee, Sang-Il;Lee, Jun-Seong
오재원;김규언;편복양;이혜란;정지태;홍수종;박강서;이수영;송상욱;김철홍;안강모;남승연;손명현;김우경;이미희;권병철;최성연;이소연;이하백;이상일;이준성

  • Published : 20030000

Abstract

Objective : Atopic dermatitis is a chronically relapsing inflammatory skin disease. However, little is known about the prevalence of atopic dermatitis outside of North America and Europe. We evaluated the nationwide prevalence of atopic dermatitis with the comparison of prevalence between 1995 and 2000, and between Seoul and provincial cities in Korea. We also evaluated the risk factors for atopic dermatitis. Methods : A cross-sectional ISAAC based questionnaire survey was conducted on random samples of schoolchildren (6 to 15 year olds) in 1995 and 2000. And kindergarten children (5year olds) were surveyed in 2003, throughout South Korea. Results : The lifetime and last twelve months prevalence of atopic dermatitis in Korean school-aged children was increased from 1995 to 2000. The twelve-month prevalence of atopic dermatitis was higher in Seoul than in other provincial cities in 1995, but the prevalence of atopic dermatitis in Seoul and Provincial Centers became similar in 2000. Conclusion : The prevalence of atopic dermatitis in Korean school-aged children was increased from 1995 to 2000. The further evaluations that include objective examination are necessary to confirm these outcomes because the environmental and risk factors may be different among the countries according to their life styles.

목 적 : 최근 세계적으로 아토피피부염과 함께 여러 알레르기질환의 유병률이 증가하는 추세이며, 특히 소아에서의 발병률은 성인에 비해 훨씬 높은 것으로 알려져 있다. 구미, 유럽에서의 유병률이 매우 높으며 이러한 추세는 치료와 예방이 개선되고 있음에도 불구하고 계속 증가하고 있다. 이에 저자들은 대한소아알레르기 및 호흡기학회 주관으로 1995년과 2000년 초등학생과 중학생, 그리고 2003년 유치원생을 대상으로 전국적인 아토피피부염 유병률의 역학적 변화와 서울과 지방과의 유병률의 차이를 알아보고 아토피피부염을 유발하거나 악화시킬 수 환경적 요인에 대하여도 알아보고자 하였다.방 법 : 1995년과 2000년에 동일한 설문방법을 이용하여 서울과 지방으로 크게 두 군으로 분류하고 나이별로는 초등학생 6-12세군과 중학생 13-15세군으로 분류하여 설문 조사하였으며, 설문 내용은 ISAAC 프로토콜을 한국어로 번역하였으며 일부 환경 설문은 국내현실에 맞게 추가하여 사용하였다. 대상자수는 1995년 조사에서 총인원 40,429명이었으며, 2000년 조사에서는 총인원 42,202명이었으며 2003년 조사에서 유치원생수는 총인원 725명이었다. 설문방법은 유치원생, 초등학생은 부모나 보호자가 응답하였으며, 중학생은 학생 본인이 응답하였다.결 과 : '지금까지의 아토피피부염'에 대한 유병률은 총인원에 대한 통계는 1995년에 비해 2000년에 유병률이 6-12세와 12-15세 모두에서 증가되었으며, '지난 12개월 동안 아토피피부염'의 발병률에서도 1995년에 비해 2000년에 대상 모든 연령에서 증가되었다. 서울이 지방에 비해 '지금까지 아토피피부염' 유병률과 '지난 12개월 동안 아토피피부염' 발병률이 1995년과 2000년 모두 높게 나타났으며, 진단율과 치료율도 서울이 지방에 비해 높게 나타났다. 1995년과 2000년에서 6-12세에서 여학생이 남학생에 비해 높은 진단율을 나타냈다. 나이에 따른 유병률은 1995년과 2000년에 서울과 지방에서 5세에서 가장 높은 유병률을 보이고, 나이가 많을수록 유병률이 감소되었다. 한편 부모의 알레르기질환과 아토피피부염 병력이 자녀의 아토피피부염 진단율에 의미있게 영향을 미치는 것으로 나타났다.

Keywords

References

  1. Sampson HA, McCaskill CC. Food hypersensitivity and atopic dermatitis : evaluation of 113 patients. J Pediatr 1985;107:669-75 https://doi.org/10.1016/S0022-3476(85)80390-5
  2. Burks AW, Mallory SB, Williams LW, Shirrell MA. Atopic dermatitis : Clinical relevance of food hypersensitivity reactions. J Pediatr 1988;113:447-51 https://doi.org/10.1016/S0022-3476(88)80626-7
  3. Barnetson RSC, Rogers M. Childhood atopic eczema. BMJ 2002;324:1376-9 https://doi.org/10.1136/bmj.324.7350.1376
  4. Sears MR. Epidemiology of childhood asthma. Lancet 1997;350:1015-20 https://doi.org/10.1016/S0140-6736(97)01468-2
  5. Williams H, Robertson C, Stewart A, Ait-Khaled N, Anabwani GA, Anderson R, et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. J Allergy Clin Immunol 1999;103:125-38 https://doi.org/10.1016/S0091-6749(99)70536-1
  6. Burr ML, Butland BK, King S, Vaughan-Williams E. Changes in the asthma prevalence: Two surveys 15 years apart. Arch Dis Child 1989;64:1452-6 https://doi.org/10.1136/adc.64.10.1452
  7. Aberg N, Hesselmar B, Aberg B, Eriksson B. Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991. Clin Exp Allergy 1995;25:815-9 https://doi.org/10.1111/j.1365-2222.1995.tb00023.x
  8. Peat JK, van der Berg RH, Green WF, Mellis CM, Leeder SR, Woolcock AJ. Changing prevalence of asthma in Australian children. BMJ 1994;308:1591-6 https://doi.org/10.1136/bmj.308.6944.1591
  9. Sugiura H, Umemoto N, Deguchi H. Prevalence of childhood and adolescent atopic dermatitis in a Japanese population : Comparison with the disease frequency examined 20 years ago. Acta Derm Venereol(Stockh) 1998;78:293-4 https://doi.org/10.1080/000155598441891
  10. Son BK, Lim DH, Kim JH, Jun YH, Kim SK. Prevalence of allergic disease and asthma related conditions in primary school-aged children and comparison of pulmonary function test between normal and children with condition related with asthma. Pediatric Allergy Resp Dis 1997;7:198-206
  11. Kim CW, Park CJ, Kim JW. Prevalence of atopic dermatitis in Korea. Acta Derm Venereol(Stockh) 2000;80:353-6 https://doi.org/10.1080/000155500459295
  12. ISAAC. ISAAC Mannual, 1st reprint. Auckland(NZ), 1993
  13. The International Study of Asthma and Allergy in Childhood(ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atpic eczema : ISAAC. Lancet 1998;351:1225-32 https://doi.org/10.1016/S0140-6736(97)07302-9
  14. Wichmann HE. Environment, life-style and allergy : the German answer. Allergy 1995;4:315-6
  15. Wieland K, Pearce N, Crane J. Prevalence of respiratory and atopic disorders among children in East and West Germany five years after unification. Eur Respir J 1999;14:862-70 https://doi.org/10.1034/j.1399-3003.1999.14d23.x
  16. Mutius E, von Gritzsch C, Weiland SK. Prevalence of asthma and allergic disorders among children in united Germany : A descriptive comparison. BMJ 1992;305:1395-9 https://doi.org/10.1136/bmj.305.6866.1395
  17. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980;92:44-7
  18. Williams HC, Pembroke AC, Burney PGF. Validation of the U.K. diagnostic criteria for atopic dermatitis in a population setting. Br J Dermatol 1996;135:12-7 https://doi.org/10.1111/j.1365-2133.1996.tb03599.x
  19. Marks R, Kilkenny M, Plunkett A. The prevalence of common skin conditions in Australian school students : II. Atopic dermatitis. Br J Dermatol 1999;140:468-73 https://doi.org/10.1046/j.1365-2133.1999.02711.x
  20. Hayashi T, Kawakami N, Kondo N. Prevalence of and risk factors for allergic diseases: Comparison of two cities in Japan. Ann Allergy Asthma Immunol 1995;75:525-9
  21. Schafer T, Kramer U, Vieluf D. The excess of atopic eczema in East Germany is related to intrinsic type. Br J Dermatol 2000;143:992-8 https://doi.org/10.1046/j.1365-2133.2000.03832.x
  22. Peat JK, van der Berg RH, Green WFl. Changing prevalence of asthma in Australian children. BMJ 1994;308:1591-6 https://doi.org/10.1136/bmj.308.6944.1591
  23. Vickers CFH. The natural history of atopic eczema. Acta Derm Venerol 1980;92:113-5
  24. Linna O, Kokkonen J, Lahtela P. Ten-year prognosis for generalized infantile eczema. Acta Paediatr 1992;81:1013-6 https://doi.org/10.1111/j.1651-2227.1992.tb12165.x
  25. Kissling S, Wuthrich B. Sites, types of manifestations and micromanifestations of atopic dermatitis in young adults : a personal follow-up 20 years after diagnosis in childhood. Hautarzt 1994;45:368-71 https://doi.org/10.1007/s001050050085
  26. Schultz Larsen F. The epidemiology of atopic dermatitis. Monogr Allergy 1993;31:9-28
  27. Schultz Larsen F. Genetic epidemiology of atopic dermatitis. In Williams HC(ed) : Atopic Dermatitis : The Epidemiology, Causes and Preention of atopic eczema. Cambridge, Cambridge University Press, 2000, pp113-24