Korean journal of dermatology (대한피부과학회지)

Korean Dermatological Association (대한피부과학회)
권호 표지

A Clinical Study on the Effect of a Cream Containing Ramulus Mori Extract and Tea Tree Oil on Acne Vulgaris and Aerobic Skin Flora

상백피 추출물과 차나무 기름 제제가 여드름과 호기성 피부 상재균에 미치는 효과

You, Jong-Yeop;Park, Seo-Hyung;Hwang, In-A;Jo, Seong-Jin;Huh, Chang-Hun;Youn, Sang-Woong;Park, Kyoung-Chan
유종엽;박서형;황인하;조성진;허창훈;윤상웅;박경찬

  • Published : 20030900
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Abstract

Background: The exact role of aerobic bacteria in the pathogenesis of acne remains controversial but several reports showed that these microorganisms were important in the development of acne lesions and affected the severity of acne by being involved in the inflammatory process. There were several attempts to improve and prevent the acne lesions by using soap or cosmetics containing anti-microbial agents. Objective: The purpose of this study was to compare the sebum secretion rates and the number of aerobic bacteria in acne patients after 4 weeks trial of RT cream containing 0.1% tea-tree oil and 0.01% Ramulus mori extract. Methods: We studied 10 normal controls and 20 acne patients. Sebum secretion was measured by Sebumeter. Clinical efficacy was evaluated by comparing numbers of non-inflammatory and inflammatory lesions. Aerobic bacteria was also cultured from control group and acne patients group before and after RT cream use. Results: Sebum secretion rates in acne patients were higher than those in control, but not statistically significant. Total number of aerobic bacteria in acne patients was higher than that in control (p<0.05). The aerobic bacteria consisted of coagulase negative Staphylococcus, Streptococcus sp., S. aureus in both acne patients and control. After 4 weeks, the number of inflammatory lesions had decreased (p<0.05%). In addition, the number of aerobic bacteria showed the tendency of decrease after RT cream use. Conclusion: RT cream consisting of 0.1% tea tree oil and 0.01% Ramulus mori extract was found to be effective and safe for acne patients with especially inflammatory lesions.

Keywords

References

  1. Pochi PE, Shalita AR, Strauss JS, Webster SB, Cunliffe WJ, Katz HI, et al. Report of the consensus conference on acne classification. J Am Acad Dermatol 1991;24:495-500 https://doi.org/10.1016/S0190-9622(08)80076-X
  2. Webster GF. Inflammation in acne vulgaris. J Am Acad Derm 1995;33:247-253 https://doi.org/10.1016/0190-9622(95)90243-0
  3. Kligman AM. An overview of acne. J Invest Dermatol 1974;62:268-287 https://doi.org/10.1111/1523-1747.ep12676801
  4. Leeming JP, Holland KT, Cunliffe WJ. The microbial colonization of inflamed acne vulgaris lesions. Br J Dermtol 1988;118:203-208
  5. Till AE, Goulden V, Cuncliffe WJ, Holland KT. The cutaneous microflora of adolescent, persistent and lateonset acne patients does not differ. Br J Dermatol 2000;142:885-892
  6. Bassett IB, Pannowitz DL, Barnetson RS. A comparative study of tea tree oil versus benzoyl peroxide in the treatment of acne. Med J Aust 1990;153:455-458
  7. Hammer KA, Carson CF, Riley TV. Susceptibility of transient and commensal skin flora to the essential oil of Melaleuca alternifolia(tea tree oil). Am J Infect Control 1996;24:186-189 https://doi.org/10.1016/S0196-6553(96)90011-5
  8. Williamson P, Kligman AM. A new method for the quantitative investigation of cutaneous bacteria. J Invest Dermatol 1965;15:498-503
  9. Burton JL, Shuster S. The relationship between seborrhea and acne vulgaris. Br J Dermatol 1971;84:600-602
  10. Harris HH, Downing DT, Stewart ME, Strauss JS. Sustainable rates of sebum secretion in acne patients and matched normal control subjects. J Am Acad Dermatol 1983;8:200-203 https://doi.org/10.1016/S0190-9622(83)70023-X
  11. Downing DT, Stewart ME, Wertz PW, Strauss JS. Essential fatty acids and acne. J Am Acad Dermatol 1986;14:221-225 https://doi.org/10.1016/S0190-9622(86)70025-X
  12. 서승리, 명기범. 정상인과 경증 여드름 환자 안면의 모낭밀도와 피지분비량에 대한 비교연구. 대피지 1998;36:787-795
  13. Pagnoni A, Kligman AM, Gammal SEL, Stoudemayer T. Determination of density of follicles on various regions of the face by cyanoacrylate biopsy; correlation with sebum output. Br J Dermatol 1994;131:862-865 https://doi.org/10.1111/j.1365-2133.1994.tb08590.x
  14. 박현정, 최성우, 채경옥, 고재숙, 김형옥, 박연준. 성인성 여드름 환자와 사춘기 여드름 환자의 지질도 및 Propionibacterium acnes 수의 비 교. 대피지 2002;38:1199-1204
  15. Wikinson JB, Moore RJ. Antiseptics. In: Harry s cosmetology. 7th ed. New York:Chemical publishing Co, 1982:91-98
  16. Kirschbaum JD, Kligman AM. The pathogenic role of Corynebacterium acnes in acne vulgaris. Arch Dermatol 1963;88:832-833 https://doi.org/10.1001/archderm.1963.01590240156026
  17. De Young LM, Young JM, Ballaron SJ, Spires DA, Puhvel SM. Intradermal injection of Propionibacterium ances: a model of inflammation relevant to acne. J Invest Dermatol 1984;83:394-398 https://doi.org/10.1111/1523-1747.ep12264715
  18. De Young LM, Spires DA, Ballaron SJ, Cummins CS, Young JM, Allison AC. Acne-like chronic inflammatory activity of Propionibacterium acnes preparations in an animal model: correlation with ability to stimulate the reticuloendothelial system. J Invest Dermatol 1985;85: 255-258 https://doi.org/10.1111/1523-1747.ep12276732
  19. Southwell IA, Hayes AJ, Markham JL, Leach DN. The search for optimally bioactive Australian tea tree oil. Acta Horticulturae 1993;334:265-275