Annals of Occupational and Environmental Medicine

The Korean Society of Occupational & Environmental Medicine (대한직업환경의학회)
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Seasonal Variations of the Urinary N-MethyIformamide Concentration among Workers at a Synthetic Leather Factory

합성피혁제조업체 근로자들의 요중 N-Methylformamide 농도의 계절적 변이

Lee, Kwang-Young;Byeon, Joo-Hyun;Song, Hae-Rhan;Kim, Jin-Ha;Ko, Kwang-Wook;Lee, Yong-Hwan
이광영;변주현;송혜란;김진하;고광욱;이용환

  • Published : 20030600
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Abstract

Objectives This study was camed out to identify seasonal variations of urinary Concentra-tions of N-methylformamide (NMF) among workers employed at a synthetic leather factory. Methods: Study subjects consisted of 16 male and 6 female workers who were involved in the direct treatment of dimethylformamide (DMF) in a synthetic leather factory By using health examination data and the results of air measurements and biologic monitoring conducted in February and July, 2001, we identified seasonal variations of the DMF concentrations in the air and NMF concentrations in urine Results:1) In winter and summer, average temperatures at the working sites were $3.2^{\circ}C$ and $26.5^{\circ}C$, respectively and average humidities were 35 4% and 84 5%, respectively 2) Airborne DMF concentrations were not significantly different between summer (13.78 ppm) and winter(11.55 ppm) 3) NMF concentrations in urine were found to be significantly higher in summer(96.09 mg/g creatinine) than in winter (31.23 mg/g creatinine) (P<0. 001) Conclusions: The seasonal difference in the urinary excretion values of NMF may be due to increased dermal absorption of DMF with the higher ambient temperature and humidity m summer and the increased area of exposed skin

목적: 본 연구는 여름과 겨울의 계절적 차이에 따른 디메틸포름아미드의 체내 흡수의 변화를 알아보고자 시행되었다. 방법: 일개 합성피혁제조업체에서 직접적으로 디메틸포름아미드를 취급하는 22명의 근로자들을 대상으로 2001년 2월(겨울)과 7월(여름)에 작업환경측정을 통해 기중 DMF농도를 측정하였고 특수건강검진을 실시하여 요중 NMF의 배설량을 측정하고 간기능 검사를 시행하였다. 또한 검사 당일의 평균 기온과 평균 습도를 측정하고 설문지를 통해 알코올 음주 정도, 피부 질환의 유무, 보호구 착용 유무 등을 조사한 후 여름과 겨울의 자료를 비교 분석하였다. 결과: 겨울과 여름의 평균 공기 중의 디메틸포름아미드 기하 평균 농도는 각각 11.55 ppm, 13.78ppm으로 통계적으로 유의한 차이는 없었으나 요중 엔-메틸포름아미드 배설량의 기하 평균은 겨울이 31.23mg/g creatinine인 것에 비해 여름이 96.09mg/g creatinine으로 겨울에 비해 여름의 요중 엔-메틸포름아미드 배설량이 유의하게 높았다(p<0.05). 공기 중 디메틸포름아미드 농도(ppm)에 대한 요중 엔-메틸포름아미드 배설량 (mg/g creatinine )의 비는 여름(1:6.97)이 겨울(1:2.70)에 비해 약 2.6배 정도 높았다. 결론: 여름과 겨울의 요중 NMF 배설량의 차이는 아마도 연구 대상 사업장의 환기 시설이 미약하고 근로자들이 DMF에 적합한 보호구를 적절하게 사용하지도 않았기 때문이고, 무엇보다도 높은 온도와 습도에서 짧은 옷을 입고 근무함으로써 피부 노출면적이 증가되어 DMF의 피부 흡수의 양이 많아졌기 때문으로 판단된다.

Keywords

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