Antioxidant, Antimutagenic and Chemopreventive Activities of a Phyto-extract Mixture Derived from Various Vegetables, Fruits, and Oriental Herbs

Kim, Ji-Hoon;Kang, Boo-Hyon;Jeong, Jong-Moon

  • Published : 20031200

Abstract

A Phyto-extract mixture derived from various vegetables, fruits, and oriental herbs was screened for antioxidant, antimutagenic, and chemopreventive activities. The phyto-extract mixture exhibited greater scavenging effects on oxygen free radicals and 1,l-diphenyl-2-picryl-hydrazyl (DPPH) radicals than that of green tea, indicating its potential to reduce cancer-causing DNA mutation induced by highly reactive free radicals. The extracts showed a strong antimutagenic activity for the mutants induced by treatment of tobacco-specific nitrosamine 4-(methylnitrosamino )-1-(3-pyridyl)-1-butanone (NNK) and $benzo[\alpha]pyren$ $(B[\alpha]P)$, exceeding that of the standard antimutagen, catechin. The phyto-extract mixture also showed chemopreventive activity, efficiently reducing NNK-induced lung cancer in A/J mice.

Keywords

References

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