Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Antitumor Activities to Cytotoxicity of Phellinus linteus Ethanol Extract

목질진흙버섯 에탄을 추출물의 세포독성에 따른 항암활성

  • 한기원 (성균관대학교 식품생명자원학과) ;
  • 이수원 (성균관대학교 식품생명자원학과) ;
  • 한광수 (대한자생식품) ;
  • 이대진 (허니머쉬 연구소) ;
  • 이병의 ((주)오스코텍, 단국대학교 첨단과학대학) ;
  • 장원철 (단국대학교)
  • Published : 2003.06.01
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Abstract

We investigated antitumor activities of the ethanol extract from mushroom Phellinus linteus and Phellinus baumii on mulberry, oak and elm. in vitro test, the ethanol extract of mushroom cultivated on oak of Phellinus linteus showed highest activities about SK-OV-3, HCT15, XF498, SK-MEL-2 and A549. SK-OV-3 cell line showed 100% cytotoxicity in 100 $\mu\textrm{g}$/ml and HCT15 (98.39%), XF498 (89.62%), SK-MEL-2 (84.07%) and A549 (79.92%) cytotoxicity respectively. Also $IC_{50}$ showed 3.99 $\mu\textrm{g}$/ml to SK-OV-3 cell line and HCT15 (4.37 $\mu\textrm{g}$/ml), A549 (5.48 $\mu\textrm{g}$/ml), SK-MEL-2 (6.72 $\mu\textrm{g}$/ml), XF 498 (6.88 $\mu\textrm{g}$/ml). As those results, cultivated oak of Phellinus linteus showed a very low $IC_{50}$ value against SK-OV-3, HCT15, XF498, SK-MEL-2 and A549 cancer cell lines.

Keywords

References

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