Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effect of Vitamin E on Cadmium Accumulation and Excretion in Chronic Cadmium Poisoned Rats

만성 카드뮴 중독 흰쥐에서 카드뮴 축적과 배설에 미치는 Vitamin E의 영향

  • Kim, Mi-Ji (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Hong, Jung-Hee (Department of Food Science and Nutrition, Catholic University of Daegu) ;
  • Rhee, Soon-Jae (Department of Food Science and Nutrition, Catholic University of Daegu)
  • 김미지 (대구가톨릭대학교 식품영양학과) ;
  • 홍정희 (대구가톨릭대학교 식품영양학과) ;
  • 이순재 (대구가톨릭대학교 식품영양학과)
  • Published : 2003.09.01
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Abstract

The purpose of this study was to investigate the effect of vitamin E on the cadmium accumulation in body, cadmium excretion and detoxification functions in chronic cadmium poisoned rats. Sprague-Dawley male rats weighing 100$\pm$10 g were randomly assigned to one normal group and three cadmium poisoned groups. Cadmium poisoned groups were classified to vitamin E free diet (Cd-0E group), vitamin E 40 mg/kg diet (Cd-400E group) and 400 mg/kg diet (Cd-400E group) according to the levels of vitamin E supplement. Animals were maintained on 0, 40 mg and 400 mg vitamin E/kg diets for 20 weeks and simultaneously administered 50 ppm Cd$^{2+}$ dissolved in the drinking water. Body weight, food intakes and food efficiency ratio were significantly decreased in all cadmium groups, compared with those of normal group. The accumulation of cadmium in rat liver, kidney and blood was reduced by sufficient vitamin E supplementation. The metallothionein (MT) content in liver and kidney were increased in all cadmium groups compared with that of normal group. The ratio of cadmium absorption and retention were significantly decreased in vitamin E supplementation groups. Accordingly, vitamin E supplementation resulted in an excretion of cadmium in urine and feces and a lowered accumulation of cadmium in liver and kidney. It can be suggested that increased MT synthesis lead to the significant decrease in cadmium absorption and retention ratios.s.

Keywords

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