Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of Seatangle Oligosaccharide Drink on Serum and Hepatic Lipids in Rats Fed a Hyperlipidemic Diet

해조 올리고당 음료의 고지혈증 유도 쥐에 있어서 혈청 및 간장의 지질 변화에 미치는 영향

  • 주동식 (동해대학교 외식산업학과) ;
  • 이진경 (강릉대학교 동해안해양생물자원연구센터) ;
  • 최용석 (강릉대학교 동해안해양생물자원연구센터) ;
  • 조순영 (강릉대학교 동해안해양생물자원연구센터) ;
  • 제외권 (동명대학 식품가공과) ;
  • 최종원 (경성대학교 약학대학)
  • Published : 2003.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

In this study, we investigated the effect of seatangle drink and seatangle extract product on weight gain and serum and hepatic lipid composition in rats fed a hyperlipidemic diet. In the dietary hyperlipidemia induced rats, it was observed that serum triglyceride, phospholipid, total lipid, LDL-cholesterol level and atherosclerotic index were higher, while the HDL-cholesterol level was lower when compared to the normal group. Total hepatic lipid and cholesterol content of the dietary hyperlipidemia induced rats was conspicuously decreased by seatangle drink and seatangle extract product treatment. Especially, triglyceride content was decreased to 30% by seatangle drink treatment, and 45% by seatangle extract product treatment.

해조 올리고당 함유 음료, 해조 음료 소재 및 해조 추출물 제품을 식이성 고지혈증을 유발시킨 실험동물에 처리하여 체중 증가, 혈중 지질성분 및 간 지질성분의 변화에 미치는 영향을 시험하였다. 식이성 고지혈증을 유도한 흰쥐에 해조 음료 및 해조 추출물 제품을 7일간 투여한 결과, 현저하게 증가되던 체중이 감소하였으며, 체중 대 간장의 무게비도 식이성 고지혈증 유도군에 비해 감소하였다. 혈청중 중성 지질 및 인지질의 함량은 식이성 고지혈증의 유도로 증가되던 것이 해조 음료 및 해조 추출물 제품의 투여로 감소되었으며, 식이성 고지혈증에 의한 혈청중 total-, LDL-, HDL-cholesterol및 동맥경화지수도 해조올리고당의 투여로서 조절되었다. 고지혈증의 유도로 증가되었던 간장 중의 총지질은 해조 음료 및 다시마 추출 음료의 투여로 현저히 감소되었으며, 지질 성분중에서 cholesterol의 함량은 혈청에서와 마찬가지로 크게 감소하였고, 중성 지질(TG, triglyceride)의 함량은 해조 올리고당 음료 식이로 30%와 다시마 추출 음료 식이로 45% 정도가 감소하는 것을 확인하였다.

Keywords

References

  1. 보건복지부. 1997. 1997년도 국민 영양 조사 결과서. 문영사, 서울. p 37.
  2. Kannel WB, Wilson PWF. 1995. An update on coronary risk factors. Med Clin North Am 79: 951-956.
  3. Grodstein F. 1997. Postmenopausal hormone therapy and mortality. N Engl J Med 336: 1769-1774. https://doi.org/10.1056/NEJM199706193362501
  4. Beaumont JL, Carlson LA, Cooper GR, Frejfar Z, Fredrickson DS, Strasser T. 1970. Classification of hyperlipidemia and hyperlipoproteinemias. Bull WHO 43: 891-897.
  5. Frings CS, Dunn RJ. 1970. A colorimetric method for determination of total serum lipids based on the sulfophosphovanillin reaction. Am J Clin Path 53: 89-92.
  6. Richmond W. 1976. Use of cholesterol oxidase for assay of total and free cholesterol in serum by continuous flow analysis. Clin Chem 22: 1579-1584.
  7. McGowan MW, Artiss JD, Strandbergh DR. 1983. A peroxidase- coupled method for the colorimetricdetermination of serum triglycerides. Clin Chem 29: 538-543.
  8. Chen PS, Toribara TY, Warnerm H. 1956. Microdetermination of phosphorus. Anal Chem 28: 1756-1760. https://doi.org/10.1021/ac60119a033
  9. Noma A, Nakayama KN, Kota M, Okabe H. 1978. Simul taneous determination of serum cholesterol in high and low density lipoprotein with use of heparin, $Ca^{2+}$ and an anion exchange resin. Clin Chem 24: 1504-1511.
  10. Folch J, Lees M, Stanley GH. 1957. A simple method for the isolation and purification of total lipds from animal tissues. J Biol Chem 226: 497-502.
  11. Ichida T. 1963. The effect of cholesterol-feeding on the tissue lipids. Hokkaido J Med Sci 38: 57-63.
  12. Joo DS, Choi YS, Cho SY. 2003. Preparation of the depolymerized alginate by physical treatment processing with organic acids. J Korean Fish Soc 36: 1-5.
  13. Choi JH, Kim DW. 1997. Effect of alginic acid-added seaweed drink (Haezomiin) in brown algae (Undaria pinnatifida) on obesity and biological activity of SD rats. Korean J Life Sci 7: 361-370.
  14. Lee JG, Lim YS, Joo DS, Joung IH. 2002. Effects of diet with seatangle (Kjellmaniella crassifolia) on calcium absortion, serum composition and feces in rats. J Korean Fish Soc 35: 601-607
  15. Jang MA, Lee KS, Seo JS, Choi YS. 2002. Effects of dietary supplementation of sea tangle extracts on the excretion of neutral steroids and bile acid in diabetic rats. J Korean Soc Food Sci Nutr 31: 819-925 https://doi.org/10.3746/jkfn.2002.31.5.819
  16. Wang C, Yang G. 1997. Comparison of effects of two kinds of soluble algae polysaccharide on blood lipid, liver lipid, platelet aggregation and growth in rats. NCBI 31: 342-345.
  17. Son HS, Kim HS, Ju JS. 1992. Effect of seaweed intake on the absorption of sodium, calcium, potassium and hypolipidemic mechanism in healthy male subjects. J Korean Soc Food Nutr 21: 471-477.
  18. Lee KS, Seo JS, Choi YS. 1998. Effect of sea tangle and hypoglycemic agent on lipid metabolism in diabetic rats. J Korean Soc Food Sci Nutr 27: 960-967.
  19. Goldstein JL, Brown MS. 1975. Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism. Am J Med 58: 147-152. https://doi.org/10.1016/0002-9343(75)90563-X
  20. Ross R. 1986. The pathogenesis of atherosclerosis, An update. New Engl J Med 314: 488-494. https://doi.org/10.1056/NEJM198602203140806
  21. Nam SM, Ham SS, Oh DH, Kang IJ, Lee SY, Chung CK. 1998. Effects of Artemisia kitamura ethanol extracts on lowering serum and liver lipids in rats. J Korean Soc Food Sci Nutr 27: 338-343.

Cited by

  1. Effects of Sea Tangle-added Patty on Postprandial Serum Lipid Profiles and Glucose in Borderline Hypercholesterolemic Adults vol.43, pp.4, 2014, https://doi.org/10.3746/jkfn.2014.43.4.522
  2. Effects of Phytoplant Diets on Body Weight, Feces Production, Body Fat, and Serum Lipid Levels in High-fat Diet-induced Hyperlipidemic Rats vol.46, pp.4, 2014, https://doi.org/10.9721/KJFST.2014.46.4.477
  3. Dietary Effects of Polymannuronate Added to Hamburger Buns on Lipid Metabolism in Rats vol.48, pp.2, 2015, https://doi.org/10.5657/KFAS.2015.0187
  4. Evaluation of Antioxidant and Nitrite Scavenging Activity of Seaweed Extracts vol.21, pp.4, 2011, https://doi.org/10.5352/JLS.2011.21.4.576
  5. Effects of Dietary Intake of Agarum cribrosum Ethanol Extract on Lipid Level in Diet-induced Obese Rats vol.29, pp.4, 2013, https://doi.org/10.9724/kfcs.2013.29.4.361
  6. Effect of Ecklonia cava Extracts Supplementation on cognitive ability in mice vol.29, pp.6, 2014, https://doi.org/10.6116/kjh.2014.29.6.103.
  7. Antioxidant and α-glucosidase inhibition activity of seaweed extracts vol.22, pp.2, 2015, https://doi.org/10.11002/kjfp.2015.22.2.290
  8. Effect of Dietary Intake of Salicornia herbacea L. Hot Water Extract on Anti-obesity in Diet-induced Obese Rats vol.41, pp.7, 2012, https://doi.org/10.3746/jkfn.2012.41.7.950
  9. The Effect of Ishige okamurae Extracts on Antioxidant Activity and Serum Lipid Content in Ovariectomized Rats vol.23, pp.12, 2013, https://doi.org/10.5352/JLS.2013.23.12.1501
  10. The Effect of Eisenia bicyclis Extracts on Antioxidant Activity and Serum Lipid Level in Ovariectomized Rats vol.22, pp.10, 2012, https://doi.org/10.5352/JLS.2012.22.10.1407
  11. α-Glucosidase, Tyrosinase, and Elastase Inhibitory Effects of Enzymatic Extracts from Ecklonia cava and its Alcohol Metabolizing Activity vol.22, pp.6, 2012, https://doi.org/10.5352/JLS.2012.22.6.751
  12. Effects of a Herbal Preparation HJ01 on Adipocyte Differentiation in OP9 Cells and the Poloxamer-407 Induced Hyperlipidemia in Mice vol.21, pp.1, 2013, https://doi.org/10.14374/HFS.2013.21.1.099
  13. The Effect of Ecklonia stolonifera Extracts on Blood Flow and Serum Lipid Level in Ovariectomized Rats vol.20, pp.12, 2010, https://doi.org/10.5352/JLS.2010.20.12.1851
  14. Effect of Seatangle Oligosaccharide Drink on Oxidation of Serum Lipid and Bleeding and Plasma Clotting Time in Rats Fed a Hyperlipidemic Diet vol.32, pp.8, 2003, https://doi.org/10.3746/jkfn.2003.32.8.1370
  15. ) Extracts vol.10, pp.3, 2007, https://doi.org/10.1089/jmf.2006.099
  16. Effects of Saury Meat on Antihyperlipidemic and Antiarteriosclerosis Activities in Sprague-Dawley Rats vol.40, pp.4, 2011, https://doi.org/10.3746/jkfn.2011.40.4.531
  17. Porphyran 음료 투여가 고콜레스테롤 유발 흰쥐의 혈청과 간중의 콜레스테롤함량에 미치는 영향 vol.34, pp.9, 2005, https://doi.org/10.3746/jkfn.2005.34.9.1357
  18. 대황유래 Laminaran이 고콜레스테롤 식이를 급여한 흰쥐의 혈청지질 성분에 미치는 영향 vol.35, pp.7, 2003, https://doi.org/10.3746/jkfn.2006.35.7.841
  19. 고지혈증 흰쥐에서 비배당체 이소플라본 고함유 대두분말의 혈청 지질 대사 영향과 항산화효과 vol.37, pp.3, 2008, https://doi.org/10.3746/jkfn.2008.37.3.302
  20. 35종 해조류 추출물의 in-vitro 항혈전 활성 평가 vol.20, pp.11, 2003, https://doi.org/10.5352/jls.2010.20.11.1640
  21. 35종 해조류 추출물의 병원성 세균 및 Candida sp. 진균에 대한 항균 활성 평가 vol.40, pp.2, 2003, https://doi.org/10.4014/kjmb.1203.03005
  22. 니파야자(Nypa fruticans Wurmb) 꽃대의 영양성분 및 항산화 활성 vol.30, pp.5, 2003, https://doi.org/10.9799/ksfan.2017.30.5.1080