Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Edible and Medicinal Plants Intake on Blood Glucose, Glycogen and Protein Levels in Streptozotocin Induced Diabetic Rats

한국산 식용 및 약용 식물의 섭취가 당뇨 유발 흰쥐의 혈당, 글리코겐 및 단백질 농도에 미치는 영향 -고본, 누룩치, 모시대 및 산초를 이용하여-

  • 임숙자 (덕성 여자대학교 자연과학대학 식품영양학과) ;
  • 한혜경 (덕성 여자대학교 자연과학대학 식품영양학과) ;
  • 고진희 (덕성 여자대학교 자연과학대학 식품영양학과)
  • Published : 2003.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

The hypoglycemic effects of four edible plants (Angelicae tenuissimae (A. ten.), Pleurospermum kamtschaticum (P. kam.), Adenophora remotiflora (A. rem.) and Zanthoxylum schinifolium (Z. sch.)) in streptozotocin (STZ) -induced diabetic rats were investigated. Sprague-Dawley male rats weighing 190-230 g were induced diabetes mellitus by the STZ injection (45 mg/kg) into the tail vein and were divided into six groups ; normal, STZ-control and four edible plant groups (A. ten., P kam., A. rem. and Z. sch. groups). Normal and STZ-control groups were fed a AIN-93 diet and four groups of STZ-induced diabetic rats were fed one of each experimental diets containing 10％ of the edible plant powder for 4 weeks. Diabetic rats showed the lower weight gain compared to the normal rats. In experimental groups except P. kam., AST activities were close to normal. A. ten. group were lowered ALT activities slightly. The plasma glucose levels of the diabetic experimental groups were significantly decreased at 4th week. The plasma insulin levels in diabetic experimental groups were not significantly different compared to the STZ-control group. The liver glycogen levels in STZ injected rats were significantly lower in compared to the normal rats. However no significant differences were found in response experimental plants intake in diabetic rats. The muscle glycogen were not significantly different among all the groups.

Keywords

References

  1. Annual report on the cause of death statistics National Statistical Office
  2. Korean Food Culture Academy Autumn Scholarship Conference Development of Food Industry and Our Food Life Guen,R.W.;Kang,S.K.
  3. Statistical annual of mortality cause The Bureau of Statistics
  4. J Korean Soc Food Nutr v.21 The trend of food and nutrition intakes of Korean (1969-1989) Park,M.A.;Kim,E.S.;Lee,K.H.;Moon,H.K.;Song,I.J.;Tchai,B.S.
  5. Diabetes melitus(12th ed.) Narle,A.;Krall,L.P.;Bradley,R.F.;Christlieb,A.R.;Soell,J.S.;Joslin's
  6. Diabetes, clinical pharmacy and therapeutics(4th ed.) Campbell,R.K.;Steil,C.F.
  7. Influence of body fat distribution on glucose tolerance and serum lipids in patient with non-insulin dependent diabetes mellitus Choi,M.S.
  8. Diabetes Care v.12 Traditional plant medicines as treatments for diabetes Bailey,C.J.;Day,C. https://doi.org/10.2337/diacare.12.8.553
  9. Korean J Pharmacogn v.21 A preliminary study on hypocholesterolemic and hypoglycemic activities of some medicinal plant Choi,J.S.;Chung,H.Y.;Young,H.S.
  10. Korean J Pharmacogn v.23 The screening of plants for hypoglycemic action in normal and alloxan-induced hyperglycemic rats Kim,O.K.;Lee,E.B.
  11. Wild vegetables good for health Yoon,K.B.;Jang,J.K.
  12. Rep Inst Health Environ v.7 Studies on the minor components of the native wild herbs growing in the mountains of Kangwon Province (Ⅰ) Lee,W.;Jeong,K.J.;Lee,H.S.;Oh,H.S.;Choi,K.Y.;Jeong,E.H.
  13. J Korean Soc Food Sci Nutr v.26 Development of beverages drinks using mountain edible herbs Ham,S.S.;Lee,S.Y.;Oh,D.H.;Kim,S.H.;Hong,J.K.
  14. J Korean Soc Food Sci Nutr v.26 no.6 Effects of the components and extracts of some edible and medicinal plants on the formation of lipid peroxide in rat liver homogenate Park,J.C.;Chung,S.K.;Hur,J.M.Lee,J.H.;Choi,M.R.;Song,S.H.;Choi,J.W.
  15. Agricultural Chem Bio v.41 Antioxidative activities of methanol extracts of tropical and oriental medicinal plants Choi,W.S.;Lee,S.E.;Lee,H.S.;Lee,Y.H.;Park,B.S.
  16. Korean J Food Sci Technol v.39 no.2 A study on the qualitative and quantitative analysis of essential oil in Angelicae tenuissimae Radix or Ligustici rhizoma Park,H.K;Lee,S.I.;Lee,S.H.;Park.H.M.;Rhee,J.S.
  17. Japan J Pharmacol v.30 A newly isolated antispasmodic-butylidenephthalide Ko,W. https://doi.org/10.1254/jjp.30.85
  18. Chem Pharm Bull v.38 Inhibitory effects of tetramethyl pyrazine and ferulic acid on spontaneous movement of rat uterus in situ Ozaki,Y.;Ma,J. https://doi.org/10.1248/cpb.38.1620
  19. Japan J Pharmacol v.60 Antiproliferative effects of the traditional chinese medicine shimotsu-to. Its component cnidium rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells Shinjiro,K. https://doi.org/10.1254/jjp.60.397
  20. Japan J Pharmacol v.63 Chemical structure-activity of cnidium rhizome-derived phthalides for the competence inhibition of proliferation in primary culture of mouse aorta smooth muscle cells Shinjiro,K. https://doi.org/10.1254/jjp.63.353
  21. Chem Pharm Bull (Tokyo) v.38 no.4 Studies on the antitumor promoting activity of naturally occurring substances Ⅱ. Inhibition of tumor promoter enhanced phospholipid metabolism by umbelliferous materials Okuyama,T.;Takata,M.;Nishiro,H.;Nishiro,A.;Takayasu.J. https://doi.org/10.1248/cpb.38.1084
  22. Korean J Appl Microbiol Bio v.28 Screening of Biologically Active Essential Oils from ligusticum tenuissimum Kim,M.H.;Kim,Y.G.;Lee,J.H.;Hong,K.P.;Hong,J.K.;Kong,Y.J.;Lee,H.Y.
  23. Korean J Soc Food Sci v.14 no.5 Analysis of volatile flavor components of Pleurospemum kamtschaticum Chung,M.S.;Lee,M.S.
  24. RDA. J Agri Sci v.38 Studies on the Cultivation of Pleuropermum kamtschaticum Hoff. as a special vegetable indigenous to high land area, 1. Ecological characteristics and environments concerning cultivation of Pleurospermum kamtschaticum Hoff Kim,J.H.;Hong,C.K.;Hong,D.G.;Bang,S.B.;Yoo,K.O.
  25. Korean Folk Medicine-Monographs Series no.3 Lee,S.J.
  26. J Korean Soc Food Nutr v.23 Further screening for antioxident activity of vegetable plants and its active principles from Zanthoxylum schinifolum Mun,S.I.;Ryu,H.S.;Lee,H.U.;Choi,J.S.
  27. J Korean Soc Food Sci Nutr v.26 Inhibition effects of Zanthoxylum schinifolium and its active principle on lipid peroxidation and liver damage in carbon tetrachloride-treated mice Mun,S.I.;Ryu,H.S.;Choi,J.S.
  28. J Nutr v.127 Components of the AIN-93 diets as improvements in the AIN-76A diet Reeves,P.G.
  29. Proc Soc Exp Biol Med v.126 Studies of the diabetogenic action of streptozotocin Junod,A.;Lambert,A.E.;Orci,L.;Picet,R.;Gonet,A.E.;Renold,A.E. https://doi.org/10.3181/00379727-126-32401
  30. J Clin Invest v.48 Diabetogenic action of streptozotocin: Relationship of dose to metabolic response Junod,A.;Lambert,A.E.;Stauffacher,W.;Renod,A.E. https://doi.org/10.1172/JCI106180
  31. Medical laboratory technology and clinical pathology(2th ed.) W.B.Saunders Co.
  32. In clinical laboratory methods(9th ed.) Bauer,J.D.
  33. Am J Clin Pathol v.28 A colorimetric method the determination of serum glutamic oxaloacetic and glutamin pyruvic transaminases Retiman,S.;Frankel,S.A.
  34. Scandinav J Lab Invest v.12 On the enzymatic determination of blood glucose Raabo,E.;Terkildsen,T.C.
  35. J Clin Endocrinol Metab v.33 Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays Desbuquois,B.;Aurbach,G.B. https://doi.org/10.1210/jcem-33-5-732
  36. Methods in Enzymology v.3 Chemical procedures for analysis of polysaccharides Hassid,W.Z.;Abraham,X. https://doi.org/10.1016/S0076-6879(57)03345-5
  37. J Bio Chem v.177 Determination of serum protein by means of the biuret reaction Gornall,A.G.;Bardawill,C.S.;David,M.M.
  38. J Bio Chem v.193 Protein measurement with the foline phenol reagent Lowry,O.H.;Rosebrough,N.J.;Farr,A.J.;Randall,R.R.
  39. PC-STAT. Rao.M.;Blane,K.;Zonnenberg,M.
  40. Diabetes v.35 STZ diabetes alters immunoreactive β-endorphin levels and pain perception after 8wk in female rats Forman,S.;Estilow,M.L.;Vailenko,P. https://doi.org/10.2337/diabetes.35.12.1309
  41. J Nutr v.123 Dietary sorbose prevents and improves hyperglycemia in genetically diabetic mice Furuse,M.;Kimura,C.;Mabayo,R.T.;Takahashi,H.;Okumara,J.
  42. Endocrinology v.119 no.6 Phenylethanolamin N-methyltransferase in the basis of STZ diabetic rats Fisher,K.J.;Stewart,J.K. https://doi.org/10.1210/endo-119-6-2586
  43. J Bio Chem v.249 Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo Pain,V.M.;Garlick,P.
  44. Diabetes v.43 Skeletal muscle vascular transport capacity in diabetic rats Sexton,W.S. https://doi.org/10.2337/diabetes.43.2.225
  45. J Korean Nutr v.27 Effects of buckwheat on organ weight, glucose and lipid metabolism in streptozotocin-induced diabetic rats Lee,J.S.;Son,H.S.;Maeng,Y.S.;Chang,Y.K.;Ju,J.S.
  46. J Korean Soc Food Nutr v.21 Pretreatment with nicotinamide to prevent the pancreatic enzymes changes by streptozotocin in rat Shon,K.H.;Kim,S.H.;Choi,J.W.
  47. Diabetes v.39 Renal kallikrein and hemodynamic abonormalities of diabetic kidney Harvey,J.N.;Jaffa,A.A.;Margolium,H.S.;Mayfield,R.K. https://doi.org/10.2337/diabetes.39.3.299
  48. Diabetes v.24 Physiologic mechanism in the development of starvation ketosis in man Grey,N.J.;Karls,I.;Kipnis,D.M. https://doi.org/10.2337/diabetes.24.1.10
  49. Diabetes v.40 Regulation of glucose metabolism in livers and kidneys of NOD mice Sococher,M.;Kunjara,S.;Baquer,N.Z.;Mclean,P. https://doi.org/10.2337/diabetes.40.11.1467
  50. Diabetes v.34 no.5 Renal hypertrophy in experimental diabetes: changes in pentose phosphate pathway activity Steer,K.A.;Sochor,M.;McLean,P. https://doi.org/10.2337/diabetes.34.5.485
  51. Diabetologia v.37 no.6 Renal proteinases and kidney hypertrophy in experimental diabetes Schaefer,L.;Schaefer,R.M.;Ling,H.;Teschner,M.;Heidland,A. https://doi.org/10.1007/BF00403374
  52. Diabetes v.38 Vasopressin in rats with genetic and streptozotocin-induced diabetes Brooks,D.P.;Nutting,D.F.;Crofton,J.L.;Share,L. https://doi.org/10.2337/diabetes.38.1.54
  53. Lipids v.26 Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics Urano,S.;Midori,H.H.;Tochihi,N.;Matsuo,M.;Shraki,M. https://doi.org/10.1007/BF02544025
  54. J Korean Soc Food Nutr v.20 The effects of nicotinamide on the serum lipid composition in streptozotocin-induced diabetic rats Choi,J.W.;Shon,K.H.;Kim,S.H.
  55. Acta Physiol Hung v.85 no.1 Oxidative stress in experimental diabetes induced by streptozotocin Matkovics,B.;Kotorman,M.;Varga,I.S.;Hai,D.Q.;Varga,C.
  56. Ann Rev Med v.36 The molecular mechanism of insulin action Kahn,C.R.
  57. Korean J Nutr v.29 Effects of vitamin E and selenium on the antioxidative defense system in streptozotocin-induced diabetic rats Lee,S.J.;Choe,W.K.;Cha,B.K.;Yang,J.A.;Kim,K.Y.
  58. Diabetes v.35 Identification of glucokinase as an alloxan-sensitive glucose senssor of the pancreatic β-cells Meglasson,M.D.;Burch,P.T.;Berner,D.K.;Najafi,H.;Matschinsky,F.M. https://doi.org/10.2337/diabetes.35.10.1163
  59. J Korean Soc Food Sci Nutr v.7 Effects of raw soy flour (yellow and black) on serum glucose and lipid concentration in streptozotocin-diabetic rats Koh,J.B.
  60. J Korean Soc Food Sci Nutr v.27 Effects of raw soy flour (yellow and black) on serum protein concentrations and enzyme activity in streptozotocin-diabetic rats Rho,M.H.;Cho,M.A.;Koh,J.B.
  61. J Korean Soc Food Sci Nutr v.31 no.2 Effect of okcheonsan on blood glucose, lipid and protein levels streptozotocin-induced diabetic female rats Koh,J.B.;Kim,J.Y. https://doi.org/10.3746/jkfn.2002.31.2.284