KOREAN JOURNAL OF CROP SCIENCE (한국작물학회지)

  • Volume 48
  • /
  • Pages.13-23
  • /
  • 2003
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  • 0252-9777(pISSN)
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  • 2287-8432(eISSN)
The Korean Society of Crop Science (한국작물학회)
권호 표지

Review on the Selenuium, an Essential Trace Mineral

기능성 미량원소 Selenium 화합물에 대한 고찰

  • Published : 2003.12.01
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Abstract

The trace mineral, selenium (Se), is an essential nutrient of fundamental importance to human health. It is also very toxic and can cause Se poisoning (selenosis) in human and animals when its intake exceeds a suitable amount. Se functions within mammalian systems primarily in the form of solenoprotein. About 35 selenoproteins have been identified, though many have not yet been fully elucidated. Selenoproteins contain Se as selenocyseine (Sec) and perform variety of structural and enzymic roles; the enzymic roles are best-known as the antioxidants for hydrogen peroxides and lipid peroxides, and the catalysts for production of activity thyroid hormone. Glutathione peroxidases ($\textrm{GP}_X$) among the selenoproteins prevent the generation of free radicals and decrease the risk of oxidative damage to tissues, as does thioredoxin reductase (TR). TR also provides reducing power for several biochemical processes. Selenoproteins P and W are involved with oxidant defense in plasma and muscle, respectively, A selenoprotein is also required for sperm motility and may reduce the risk of miscarriage. Some epidemiological studies have revealed an inverse correlation between Se status and cardiovascular disease, and there is considerable evidence 1mm population com-parison data and animal studies that Se is anticarcinogenic. It is also suggested that Se should be needed for the proper functioning of the immune system, and appear to be a key nutrient in counteracting the development of virulence and inhibiting HIV progression to AIDS. As research continues, the role of selenium in the etiology of chronic diseases like appropriate medical nutrition therapy can be delivered and its effectiveness assessed. Se status in individuals is affected by diet and the availability of the Se. The Se content of plants is affected by the content and availability of the element in the soil in which they are grown, and so greatly varies from country to country, while the Se composition of meat reflects the feeding patterns of livestock. This paper provides an overview on Se as an essential trace mineral for human.

Keywords

References

  1. Albright J. W., and J. F. Albright. 1998. Impaired natural killer cell function as a consequence of aging. Exp Gerontol. 33 : 13-25 https://doi.org/10.1016/S0531-5565(97)00099-5
  2. Aro A., G. Alfthan, and P. Varo. 1995. Effects of supplementation of fertilizers on human selenium status in Finland. Analyst 120 : 841- 843 https://doi.org/10.1039/an9952000841
  3. Arteel, G, E., and H. Sies. 2001. The biochemistry of selenium and the glutathione system. Environmental Toxicology and Pharmacology 10 : 153-159 https://doi.org/10.1016/S1382-6689(01)00078-3
  4. Arthur J. R., and G. J. Beckett. 1999. Thyroid function: review. Br. Med. Bull. 55 : 658-568 https://doi.org/10.1258/0007142991902538
  5. Aukrust P, A. M. Svardal, F. Muller, B. Lunden, et al. 1995. Increased levels of oxidized glutathione in CD4+1ymphocytes associated with disturbed intracellular redox balance in human immunodefi- ciency virus type 1 infection. Blood 86 : 258-267
  6. Barclay M. N. I., A. MacPherson, and J. Dixon. 1995. Selenium content of a range of U.K. foods. J.Food Comp. Anal. 8 : 307-318 https://doi.org/10.1006/jfca.1995.1025
  7. Bock A., K. Forchhammer, H. Heider, W. Leinfelder, G. Sawers, B. Voprek, and F. Zinoni. 1991. Selenocystein: the 21st amino acid. MoI. MicrobioI. 5 : 515-520 https://doi.org/10.1111/j.1365-2958.1991.tb00722.x
  8. Brigelius-Flohe R. 1999. Review: tissue-specific functions of individual glutathione peroxidases. Free Radic. Biol. Med. 27 : 951-965
  9. Cheng Y. Y., and P. C. Qian. 1990. The effect of selenium-fortified table salt in the prevention of Keshan disease on a population of 1.05 million. Biomed. Environ. Sci. 3 : 422-428
  10. Contempr B., J. E. Dumont, J.-F. Denef, and M.-C. Many. 1995. Effects of selenium deficiency on thyroid necrosis, fibrosis and proliferation: a possible role in Myxoedematous cretinism. J. Eur. Endocrinol. 133 : 99-109 https://doi.org/10.1530/eje.0.1330099
  11. Davis C. D., H. Zeng, and J. W. Finley. 2002. Selenium enriched broc- coli decreases intestinal tumorigenesis in multiple intestinal neo- plasia mice. J. Nutr. 132 : 307-309
  12. Deagen J. T, J. A. Butler, and B. A. Zachara. 1993. Whanger PD. Determination ofthe distribution of Se between glutathione perox- idase, selenoprotein P and albumin in plasma. Anal. Biochem. 208 : 176-184 https://doi.org/10.1006/abio.1993.1025
  13. Diaz-Alarcon J. P., M. Navarro-Alarcon, et al. 1996. Determination of selenium in cereals, legumes and dry fruits from southeastern Spain for calculation of daily dietary intake. The Sci. of The TotaI Environment 184 : 183-189 https://doi.org/10.1016/0048-9697(96)05079-6
  14. Fairweather-tait S. J. 1997. Bioavailability of selenium. Eur. J. Clin. Nutr.Sl :S20-23
  15. Fang Y.-Z., S. Yang, and G. Wu. 2002. Free radicals, antioxidants, and Nutrition. Nutrition 18 : 872-879 https://doi.org/10.1016/S0899-9007(02)00916-4
  16. Farady, J. J., C. D. McOriist, and Y. J. Farrar. 1989. The determination of selenium in the Australian diet using neutron activation analysis.J. Radioanal. Nuct. Chem. A. 133 : 391-396 https://doi.org/10.1007/BF02060511
  17. Finley J., L. Matthys, T. Shuler, and E. Korynta. 1996. Selenium con- tent offoods purchased in North Dakota. Nutr. Res. 16 : 723-728 https://doi.org/10.1016/0271-5317(96)00062-0
  18. Gladyshev V. N., D. L. Hatfield. 1999. Review : selenocysteine-con- taining proteins in mammals. J. Biomed. Sci. 6 : 151-160 https://doi.org/10.1007/BF02255899
  19. Gladyshev V. N., D. L. Hatfield. 1999. Review : selenocysteine-con- taining proteins in mammals. J. Biomed. Sci. 6 : 151-160 https://doi.org/10.1007/BF02255899
  20. Glattre E., Y. Thomassen, S. O. Thoresen, T. Haldorsen, et at. 1989. Prediagnostic serum selenium in a case-control study of thyroid cancer, Int. J. Epidemiol. 18 : 45-49 https://doi.org/10.1093/ije/18.1.45
  21. Gu Q-P, Y. Sun, L. W. Ream, and P. D. Whanger. 2000. Se-W accu- mulates primarily in primate skeletal muscle, heart, brain and tongue. Mol. Cell Biochem. 204 : 49-56 https://doi.org/10.1023/A:1007065829068
  22. Hill K. E., Y. Xia, B. Akesson, et al. 1996. Se-P conc. in plasma as an index of Se status in Se deficient and Se supplemented Chinesesubjects. J. Nutr. 126 : 138-145
  23. Hirai K., K. Noda, and H. Danbara. 1996. Selenium intake based on representative diets in Japan, 1957 to 1989. Nutrition Research 16: 1471-1477 https://doi.org/10.1016/0271-5317(96)00160-1
  24. Ip C., 1998. Lessons from basic research in selenium and cancer prevention. J. Nutr. 128 : 1845-1854
  25. McNaughton S. A., and G. C. Marks. 2002. Selenium Content of Aus-tralian Foods: a review of literature values. J. Food Composition and Ana1ysis 15 : 169-182 https://doi.org/10.1006/jfca.2002.1047
  26. Mostert V. 2000. Selenoprotein P: properties, functions, and regula- tion.Arch. of Biochem. and Biophy. 376 : 433-438 https://doi.org/10.1006/abbi.2000.1735
  27. Murphy J., and K. D. Cashman. 2001. Selenium content of a range of Irish foods. Food Chemistry 74 : 493-498 https://doi.org/10.1016/S0308-8146(01)00169-8
  28. Navarro-Alarcon M., and M. C. Lopez-Martinez. 2000. Essentiality of selenium in the human body : relationship with different diseases. Sci. of Tot. Environ. 249 : 347-371 https://doi.org/10.1016/S0048-9697(99)00526-4
  29. Olivieri 0., D. Girelli, M. Azzini, A. M. Stanzial, et al. 1995. Low selenium status in the elderly influences thyroid hormones. Clin. Sci.(Lond). 89 : 637-642
  30. Oster, O., and W. Prellwitz. 1989. The daily dietary selenium intake of West German adults. Bio Trace Element Research. 29 : 1-14
  31. Peng A., W. H. Wang, et al. 1999. The role of humic substances in drinking water in Kashin-Beck disease in China. Environ. Health Perspect. 107 : 293-296 https://doi.org/10.1289/ehp.99107293
  32. Rayman M. P. 2000. The importance of selenium to human health. The Lancet 356: 233-241 https://doi.org/10.1016/S0140-6736(00)02490-9
  33. Reilly C. 1998. Selenium: A new entrant into the fuctional food arena. Trends in Food Sci. & Technol. 9 : 114-118 https://doi.org/10.1016/S0924-2244(98)00027-2
  34. Rotruck J. T., A. L. Pope, H. E. Ganther, et al. 1973. Selenium: bio- chemical role as a component of glutathione peroxidase. Science 179 : 588-590 https://doi.org/10.1126/science.179.4073.588
  35. Serra V., T. Grune, N. Sitte, G. Saretzki, and T. von Zglinicki. 2000. Telomere length as a marker of oxidative stress in primary human fibroblast cultures. Ann. N.Y.Acad. Sci. 908 : 327-330 https://doi.org/10.1111/j.1749-6632.2000.tb06666.x
  36. Stadlober, M., M. Sager, and K. J. Irgolic. 2001. Effects of selenate supplemented fertilisation on the selenium level of cereals - identi- fication and quantification of selenium compounds by HPLC-ICP- MS. Food Chem. 73 : 357-366 https://doi.org/10.1016/S0308-8146(01)00115-7
  37. Commans S., and A. Bock. 1999. Selenocysteine inserting tRNA: an overview. REMSMicrobiol. Reviews 23 : 335-351 https://doi.org/10.1111/j.1574-6976.1999.tb00403.x
  38. Tapiero H., D. M. Townsend, and K. D. Tew. 2003. The antioxidant role of selenium and seleno-compounds. Biomedicine & Pharma- cotherapy57 : 134-144 https://doi.org/10.1016/S0753-3322(03)00035-0
  39. Thompson H. J., A. Wilson, J. Lu, et al. 1994. Comparison of the effects of an organic and an inorganic form of selenium on a mammary carcinoma cell line. Carcinogenesis 15 : 183-186 https://doi.org/10.1093/carcin/15.2.183
  40. Tinggi U. 2003. Essentiality and toxicity of selenium and its status in Australia. Toxicology Letters 137 : 103-110 https://doi.org/10.1016/S0378-4274(02)00384-3
  41. Vadhanavikit S., C. IP, and H. Ganther. 1993. Metabolites of sodium selenite and methylated selenium compounds administered at cancer chemoprevention levels in the rat. Xenobiotica 23 : 731-745 https://doi.org/10.3109/00498259309166780
  42. Willett W. C., B. F. Polk, and J. S. Morris. 1983. Stampfer M. J, Pres- sel S, Rosner B, et al. Prediagnostic serum selenium and risk of cancer. Lancet. 2 : 130-134
  43. Willett W. C., B. F. Polk, and J. S. Morris. 1983. Stampfer M. J, Pressel S, Rosner B, et al. Prediagnostic serum selenium and risk of cancer. Lancet. 2 : 130-134
  44. Wn L,, J. Lanfear, and P. R. Harrison. 1995. The Se metabolite Se- diglutathione induces cell death by a mechanism distinct from $H_2O_2$ toxicity. Carcinogenesis 16 : 1579-1584 https://doi.org/10.1093/carcin/16.7.1579
  45. Wyatt C. J., J. M. Melendez, N. Acuna, and A. Rascon. 1996. Sele- nium (Se) in foods in northern Mexico, their contribution to the daily Se intake and ther relationship of Se plasma levels and glu- tathione peroxidase activity. Nutrition Reseach 16 : 949-960 https://doi.org/10.1016/0271-5317(96)00094-2
  46. Yang C, C. Niu, M. Bodo, et al. 1993. Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue. An animal model to study the molecular defects of Kashin-Beck disease. Biochem. J. 289 : 829-835
  47. Yang, G., S. Wang, R. Zhou, and S. Sun. 1983. Endemic selenium intoxication of humans in China. Am. J. Ctin. Nutr. 37 : 872-881