Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Effect of BNs-3 and BNs-7, Extracts of Citrous Orange Peel, on the Obesity Induced by ad libitum Feeding a Cholesterol-Containing Diet in Rats

콜레스테롤 함유 식이 랫드에서 감귤껍질추출물 BNs-3 및 BNs-7의 항비만 효과

  • Chai, Hee-Youl (College of Veterinary Medicine, Chungbuk National University) ;
  • Sin, Ji-Soon (College of Veterinary Medicine, Chungbuk National University) ;
  • Kwon, Woon (College of Veterinary Medicine, Chungbuk National University) ;
  • Choi, Ehn-Kyoung (College of Veterinary Medicine, Chungbuk National University) ;
  • Cho, Young-Min (College of Veterinary Medicine, Chungbuk National University) ;
  • Zhang, Hu-Song (College of Veterinary Medicine, Chungbuk National University) ;
  • Hwang, Seock-Yeon (College of Medicine, Chungbuk National University) ;
  • Bok, Song-Hae (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Yun-Bae (College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Jong-Koo (College of Veterinary Medicine, Chungbuk National University)
  • 채희열 (충북대학교 수의과대학) ;
  • 신지순 (충북대학교 수의과대학) ;
  • 권운 (충북대학교 수의과대학) ;
  • 최은경 (충북대학교 수의과대학) ;
  • 조영민 (충북대학교 수의과대학) ;
  • 장호송 (충북대학교 수의과대학) ;
  • 황석연 (충북대학교 의과대학) ;
  • 복성해 (한국생명공학연구원) ;
  • 김윤배 (충북대학교 수의과대학) ;
  • 강종구 (충북대학교 수의과대학)
  • Published : 2003.09.01
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Abstract

The protective effects of BNs-3 and BNs-7, extracts of citrous orange peel, on the obesity induced by ad libitum feeding a cholesterol-containing diet to rats were investigated. The animals were fed on the diet including cholesterol (0.5%) with or without the citrous orange peel extracts BNs-3 (5%) and/or BNs-7 (0.1%) for 8 weeks. The ad libitum feeding a diet containing cholesterol to rats from 6 weeks of age increased the body weight gain compared with that of rats fed on a normal diet. Such an increase in body weights was markedly attenuated by the addition of BNs-3 or BNs-7 to the diet. Especially, a combinational feeding on BNs-3 and BNs-7 significantly reduced the body weight gain below that of normal diet-fed animals. Interestingly, the weights of abdominal adipose tis-sues surrounding epididymides were greatly reduced by the citrous orange peel extracts, in parallel with the decrease in body weights. In addition, blood concentrations of lipids including cholesterol were also lowered by the combinational treatment with BNs-3 and BNs-7. Taken together, it is suggested that the obesity and overweight produced by unrestricted overfeeding on diet with cholesterol may be partially due to the accumulation of abdominal adipose tissues, around the epididymides in rats, and that citrous orange peel extracts might exert antiobese activities by reducing the adipose tis-sues as well as blood lipid concentrations.

Keywords

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