Abstract
Purpose : Nowadays, there are many studies of growth retardation treatment by oriental medical therapy. This study was performed to evaluate the effect of Hwalhyulsungjang-san (Huoxuechengzhang-san) and KC101 on physical development in growth, Methods : 60 young (3 weeks old) male rats, whose mean weight was $46.8{\pm}0,7g$, were divided into 5 groups : groups A, B, C, and D were fed an experimental diet containing respectively Hwalhyulsungjang-san 2.5%, Hwalhyulsungjang-san 7.5%, KC101 5.0%, and KC101 10.0%, and the other group were fed an AIN-diet containing neither Hwalhyulsungjang-san nor KC101 as a control. Study of each group used 2 rats and was repeated in 6 times. Body weight, daily weight gain, dietary intake, body length, femur length, backbone length and serum concentration of IGF-I and hemoglobin were measured. Result : 1. Body weight and daily weight gain of group D (KC101 10%) were highest; dietary intake of group D was also increased by 13% over the control group. 2. Average body length of group D was increased to 1.69cm, which was 3.2% over the control group. Backbone length of group D was also increased 4% compared to control group. 3. Serum concentration of IGF-I of group D increased 17% compared to control group. 4. Serum concentration of hemoglobin of group B (Hwalhyulsungjang-san 7.5%) increased 8% compared to control group. Conclusion : This study showed that Hwalhyulsungjang-san and KC101 composed of oriental medicinal stuffs have effect on physical development in growing rats. There were not any statistical meaning compared to control group, but this study suggests that intake of these compounds from a young age may lead to increase physical development in growth.
