The Experimental Study on the Anti-allergic Effects of Sipjeondaebo-tang

십전대보탕이 알레르기반응에 미치는 영향

  • Park Dong Il (Department of Internal Medicine, College of Oriental Medicine Dongeui University) ;
  • Park Bong Kyu (Department of Internal Medicine, College of Oriental Medicine Dongeui University) ;
  • Kim Won Ill (Department of Internal Medicine, College of Oriental Medicine Dongeui University)
  • 박동일 (동의대학교 한의과대학 내과학교실) ;
  • 박봉규 (동의대학교 한의과대학 내과학교실) ;
  • 김원일 (동의대학교 한의과대학 내과학교실)
  • Published : 2003.04.01

Abstract

This experimental research has been done to study the effects of Sipjeondaebo-tang(SOT) on the anti-allergic reaction. We found the several important results from the research which has been performed by two experiments toward immediately type and delayed type in order to study the effects of SDT on hypersensitivity response to mice. The results obtained from our research are as following. The survival rate of one group to which we injected only the compound 48/80 is almost 0% according to its density and timing test. In the other hand, the survival rates of the other group to which we injected both of the compound 48/80 and SDT are 20%, 10%, 30%, 10%, 40% and 70% according to 0.025, 0.05, 0.1, 0.25 0.5 and 1 (mg/g) of compound 48/80. Time dependency test also shows the 30% and 20% survival rates in 5 and 10 minutes. SDT revealed the significantly inhibitory effect on Compound 48/80 induced Mast cell degranulation. SDT showed the significantly inhibitory effect in the delayed type hypersensitivity response to picry1 chloride. SDT showed the significantly inhibitory effect in the delayed type hypersensitivity response to sheep red blood cell. Our research provides the important evidence that SDT is benificial to the prevention and treatment of allergy related diseases.

Keywords

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