Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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The Effects of Polymannuronate on Leptin in Serum and Liver of Rats

Polymannurongte가 흰쥐의 혈청과 간장조직중의 Leptin에 미치는 영향

  • KIM In Hye (Faculty of Food Science and Biotechnology, Pukyong National University) ;
  • LEE Dong Soo (Biotechnology Research Center, KBP Co. Ltd.) ;
  • KWON Ji Young (Faculty of Food Science and Biotechnology, Pukyong National University) ;
  • KWON Mi Jin (Faculty of Food Science and Biotechnology, Pukyong National University) ;
  • NAM Teak Jeong (Faculty of Food Science and Biotechnology, Pukyong National University)
  • Published : 2003.12.01
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Abstract

This study investigated the effects of polymannuronate feeding on cholesterol levels and leptin in the serum and liver of Sprague-Dawely rats. After one week of basal diet feeding, four week old S.D. male rats were fed with polymannuronate. The feeding efficiency of the polymannuronate fed group averaged around 0.27, which was 0.02-0.03 lower than that of the control group, and liver weight, also had a lower increase. The liver tissue tagging of rats by staining fat drops increased in the cholesterol fed group. RIA and RT-PCR were used to determine the expression of leptin in the serum and liver of rats. The polymannuronate fed group had a larger reduction in the serum and liver leptin than the cholesterol fed group. The RT-PCR results showed that leptin mRNA was expressed in the liver. The polymannuronate fed group had a larger reduction in liver leptin mRNA expression than the cholesterol fed group. The above results suggest that feeding of polymannuronate improves the physiological function of rats by changing serum and liver lipid composition and the expression of leptin was repressed at a molecular level.

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References

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