The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 25 Issue 3
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- Pages.518-528
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- 2004
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- 1226-9174(pISSN)
The Effects of Hyangsapyeongwisan on Gastric Mucosal Lesions Induced by Indomethacin
Indomethacin으로 유발된 생쥐의 위 점막 손상에 대한 향사평위산(香砂平胃散)의 보호 효과
- Choi, Heung-Min (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
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Lim, Seong-Woo
(Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
- Published : 2004.09.30
Abstract
This study was carried out to investigate the effects of Hyangsapyeongwisan(HP) on gastric mucosal lesions induced by indomethacin in mice. The control group consisted of gastro-inflammation elicited mice. The sample group consisted of mice given HP after onset of gastro-inflammation. In common morphological and histochemical change, various cell abnormalities were observed in the control group, such as mucous surface cell, peanut cell, surface epithelial cell, goblet cell abnormalities, all caused hemorrhagic erosion. The sample group was the same as the control group. In the immunohistochemical change, the distributions of COX-I, BrdU treated with HP were notably higher than those of the control group(p
Keywords
- Hyangsapyeongwisan;
- the injury of gastric mucosal membrane;
- COX-1;
- $NF-{\kappa}B$;
- PKC;
- indomethacin