Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The effects of Jowiseungchungtang versus fluoxetine in the chronic mild stress model of depression in rats

우울증(憂鬱症)모델 흰쥐에 대한 조위승청탕(調胃升淸湯)과 fluoxetine의 항우울효과(抗憂鬱效果) 비교

  • Ryu, Jae-Myun (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Jong-Woo (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyung-Hee University) ;
  • Chi, Sang-Eun (Dept. of Psychology, Korea University) ;
  • Kim, Eun-Joo (Dept. of Psychology, Korea University) ;
  • Park, Eun-Hye (Dept. of Psychology, Korea University) ;
  • Hwang, Ui-Wan (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyung-Hee University)
  • 류재면 (경희대학교 한의과대학 신경정신과교실) ;
  • 김종우 (경희대학교 한의과대학 신경정신과교실) ;
  • 지상은 (고려대학교 심리학과) ;
  • 김은주 (고려대학교 심리학과) ;
  • 박은혜 (고려대학교 심리학과) ;
  • 황의완 (경희대학교 한의과대학 신경정신과교실)
  • Published : 2004.06.30
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Abstract

This study was performed to evaluate the effects of Jowiseungchungtang and fluoxetine in the chronic mild stress(CMS) model of depression in rats. Chronic exposure to mild unpredictable stress was found to depress the consumption of sucrose solution in rats for 5 weeks. These CMS-treated rats were stratified into Jowiseungchungtang group, fluoxetine group and vehicle group. And control rats were also stratified into other CMS-treated group. The change of the consumption of sucrose solution was measured, and open field test were performed to investigate the anti-depression effect of Jowiseungchungtang and fluoxetine. The results were as follows : 1. The consumption of sucrose solution was significantly reversed in Jowiseungchungtang-treated group at 7 week, but there was no significant change in other groups. 2. CMS schedule decreased body weight. Jowiseungchungtang group and fluoxetine group showed significant decrease of body weight after 6 weeks. 3. In open field test, Jowiseungchungtang group and fluoxetine group showed no significant change of exploratory activity.

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