Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Preparation and In Vitro Test of Sold Dispersion using Acyclovir and Water Soluble Polymer

아시클로비어와 수용성 고분자를 이용한 고체분산체 제조 및 생체외 방출

  • Ahn, Yong-San (Department of Polymer.Nano Science and Technology Chonbuk National University) ;
  • Lee, Ha-Young (Department of Advanced Organic Materials Engineering, Chonbuk National University) ;
  • Hong, Keum-Duck (Department of Polymer.Nano Science and Technology Chonbuk National University) ;
  • Jung, Sung-Beum (Department of Polymer.Nano Science and Technology Chonbuk National University) ;
  • Cho, Sun-Hang (Nanobiomaterials Laboratory Korea Research Institute of Chemical Technology) ;
  • Rhee, John-Moon (Department of Polymer.Nano Science and Technology Chonbuk National University) ;
  • Lee, Hai-Bang (Nanobiomaterials Laboratory Korea Research Institute of Chemical Technology) ;
  • Khang, Gil-Son (Department of Polymer.Nano Science and Technology Chonbuk National University)
  • 안용산 (전북대학교 고분자.나노공학과) ;
  • 이하영 (전북대학교 유기신물질 공학과) ;
  • 홍금덕 (전북대학교 고분자.나노공학과) ;
  • 정성범 (전북대학교 고분자.나노공학과) ;
  • 조선행 (한국화학연구원 생체의료고분자팀) ;
  • 이종문 (전북대학교 고분자.나노공학과) ;
  • 이해방 (한국화학연구원 생체의료고분자팀) ;
  • 강길선 (전북대학교 고분자.나노공학과)
  • Published : 2004.06.20
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Abstract

Acyclovir(ACV) is an important antiviral drug used extensively against infections caused by herpes viruses, especially herpes simplex and varicella zoster. Because of high crystallinity and large particle size, solubility of intact ACV is very low in water(1.3 mg/ml). The goal of this work is to enhance the solubility of ACV. To make solid dispersion, Polyethyleneglycol, Hydroxyprophylmethylcelluose and Polyvinylpyrrolidone were used as polymer carriers in this work. Polymer carriers and drug were dissolved in acetic acid. And then spray drying method and freeze drying method were used as solvent extraction. Morphology, crystallization and functional group were characterized using SEM, XRD and FT-IR. The result of in vitro test showed the sample using PVP as polymer carrier had higher dissolution rate(up to 466%) than intact ACV.

Keywords

References

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