Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Biological Activity of Polyphenol Group Fraction from Korean Pear Peel

한국산 배과피 폴리페놀 분획군의 생리활성효과

  • An, Bong-Jeun (Department of Cosmetic Engineering Daegu Haany University) ;
  • Lee, Jin-Tae (Department of Cosmetic Engineering Daegu Haany University) ;
  • Kwak, Jae-Hoon (Department of Cosmetic Engineering Daegu Haany University) ;
  • Park, Jung-Mi (Department of Cosmetic Engineering Daegu Haany University) ;
  • Lee, Jin-Young (Department of Cosmetic Engineering Daegu Haany University) ;
  • Son, Jun-Ho (Department of Cosmetic Engineering Daegu Haany University) ;
  • Bae, Jong-Ho (Department of Confectionery Decoration, Daegu Mirae College) ;
  • Choi, Cheong (Department of Food Science and Technology, Yeungnam University)
  • 안봉전 (대구한의대학교 화장품공학과) ;
  • 이진태 (대구한의대학교 화장품공학과) ;
  • 곽재훈 (대구한의대학교 화장품공학과) ;
  • 박정미 (대구한의대학교 화장품공학과) ;
  • 이진영 (대구한의대학교 화장품공학과) ;
  • 손준호 (대구한의대학교 화장품공학과) ;
  • 배종호 (대구미래대학) ;
  • 최청 (영남대학교 생물산업공학부)
  • Published : 2004.03.31
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Abstract

Biological activities and anticarcinogenicity of Korean Pear peel were investigated, Electron donating activity and superoxide dismutase (SOD)-like activity of fraction II, III were up to 80% and 50-60% at 50 ppm, respectively, Inhibitory effects on xanthine oxidase were about 80% at 50 ppm, breast adenocarcinoma was about 60% at 2,000 ppm, higher III than II Inhibitory effect on prostate adenocarcinoma was about 23% at 500 ppm. In conclusion, Korean pear peel was expected to use as a functional material.

한국산 배과피의 기능성 원료로서의 가능성을 알아보기 위하여 폴리페놀 성분을 분획하여 그 생리활성 및 암세포증식능에 대하여 살펴보았다. 전자공여능에서는 50 ppm에서 분획물 II, III에서 80% 이상으로 나타났으며 SOD 유사능은 분획물 II, III의 500 ppm군에서 50-60%의 효과가 인정되었다. 통풍과 관련있는 xanthin oxidase 실험에서는 분획물 I의 저해 효과는 미미하였으나 II와 III에서는 50 ppm에서도 80%에 이르는 높은 저해효과가 관찰되었으며, 유선암세포(MDA) 생육억제 실험에서는 분획물 II보다 III가 높은 증식억제능을, 2,000 ppm에서는 약 60%의 억제능을 나타내었고, 전립선암(PC-3)의 세포억제효과에서는 III보다 II에서 오히려 억제 효과가 높았고, 500 ppm에서 약 23%의 억제효과가 관찰되어 한국산 배과피의 기능성 소재로서의 가능성을 확인할 수 있었다.

Keywords

References

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