Journal of the Korean Society of Food Culture (한국식생활문화학회지)

Korean Society of Food Culture (한국식생활문화학회)
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Effects of Dietary Sea Tangle on Blood Glucose, Lipid and Glutathione Enzymes in Streptozotocin-Induced Diabetic Rats

다시마 분말이 당뇨 유발쥐의 혈당과 지질농도 및 항산화 효소계에 미치는 영향

  • Cho, Young-Ja (Department of Food & Nutrition, Mokpo National University) ;
  • Bang, Mi-Ae (Department of Food & Nutrition, Mokpo National University)
  • 조영자 (목포대학교 생활과학부 식품영양전공) ;
  • 방미애 (목포대학교 생활과학부 식품영양전공)
  • Published : 2004.08.31
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Abstract

The Purpose of this study was to investigate the effect of dietary sea tangle in diabetic rats treated with streptozotocin(STZ). Four groups of rats (Sprague-Dawley male rats,180-200g) were normal rats fed control diet(C), diabetic rats fed control diet(CD), normal rats fed sea tangl diet(T), and diabetic ,rats fed sea tangle diet(TD), diabetes was induced by single injection of streptozotocin(60mg/kg B.W.). High density lipoprotein(HDL) of T and TD group were higher than other groups(C and T groups). And the weekly change of blood sugar was decreased in the 3th and 4th weeks. But serum triglyceride (TG) of diabetic rats fed sea tangle diet(TD) was lower than diabetic rats fed control dlet(CD). Activity of hepatic microsomal Glucose 6-phosphatase(G6Pase) was significantly increased CD and TD groups higher than C and T groups. Hepateic glutathione S-transferase(GST of T, CD and TD groups were significantly lower than C group(p<0.05), glutathione peroxidase (GPX) of T and TD groups were significantly higher than C and CD groups(p<0.05).

다시마 분말 첨가식이가 당뇨쥐의 당질과 지질대사 및 항산화효소계에 미치는 영향을 규명하기 위하여 SD계 횐쥐에 17% 다시마 분말을 급여하여 7주간 실험 사육한 후 혈청의 포도당 및 지질농도와 주요장기의 항산화효소의 활성도를 관찰하였다. 다시마 당뇨군(TI)에서 다사마 섭취는 당뇨에 의한 체중감소 현상을 보였다. 당뇨군의 혈당 농도는 다시마 섭취에 의한 혈당강하 효과는 3주째에 나타났다. 당뇨에 의한 산화적 스트레스로 인해 증가한 GST 활성도가 다시마 섭취로 인해 정상 수준으로 저하됨으로써 다시마의 섭취가 당뇨시 산화적 반응에 대한 방어기전을 제공할 수 있음을 유추할 수 있었다. 또한 중성지방이 감소하고 HDL-콜레스테롤의 증가하는 경향으로 심혈관계와 관련되는 당뇨합병증의 억제 가능성을 제시하였다.

Keywords

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