The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Antihypertensive effect of Chunghyul-dan(Qingxue-dan) on stage 1 hypertensive patients with stroke

중풍환자 1기 고혈압에 청혈단(淸血丹)의 항고혈압 효과

  • Kim, Lee-Dong (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Lee, Sang-Ho (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Eun-Ju (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Tai-Hun (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Young-Min (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Jung, Dong-Won (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Shin, Won-Jun (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Jung, Woo-Sang (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Bae, Hyung-Sup (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University) ;
  • Yun, Sang-Pil (Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University)
  • 김이동 (경희대학교 한의과대학 2 내과학 교실) ;
  • 이상호 (경희대학교 한의과대학 2 내과학 교실) ;
  • 김은주 (경희대학교 한의과대학 2 내과학 교실) ;
  • 김태훈 (경희대학교 한의과대학 2 내과학 교실) ;
  • 박영민 (경희대학교 한의과대학 2 내과학 교실) ;
  • 정동원 (경희대학교 한의과대학 2 내과학 교실) ;
  • 신원준 (경희대학교 한의과대학 2 내과학 교실) ;
  • 정우상 (경희대학교 한의과대학 2 내과학 교실) ;
  • 배형섭 (경희대학교 한의과대학 2 내과학 교실) ;
  • 윤상필 (경희대학교 한의과대학 2 내과학 교실)
  • Published : 2004.06.30
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Abstract

Background and Purpose : Hypertension is one of the modifiable risk factors for stroke. Lowering blood pressure is a primary or secondary preventative measure for stroke. This study aims to assess the efficacy of Chunghyul-dan(Qingxue-dan) in stage 1 hypertensive patients who have suffered a stroke by 24 hour ambulatory blood pressure monitoring(24ABPM). Subjects& Methods : We enrolled 40 hospitalized stroke patients with stage 1 hypertension and divided them into 2 groups by stratified randomization; group A took 1200mg of Chunghyul-dan(Qingxue-dan) at 8:00 a.m. for two weeks without changing herbal medicine, and group B was the control group. 28 patients were included in the final analysis(15 in group A. 13 in group B). Blood pressure is monitored from 8:00 am to 7:30 am every 30 minutes for 24 hours. Blood pressure was monitored two times at baseline and again two weeks later. We used 3 parameters for evaluating the efficacy of Chunghyul-dan(Qingxue-dan); The first parameter is change from baseline to two weeks later in blood pressure and pulse rate. The second parameter is the trough/peak ratio(TPR) and smoothness index(SI). The third parameter is antihypertensive rate by antihypertensive efficacy guideline. Results : There is no significant difference in the baseline assessment hetween the two groups. Systolic blood pressure $(141.37{\pm}8.96\;mmHg\;vs\;132.28{\pm}9.46\;mmHg)$ decreased after two weeks of 1200mg(P=0.03) intake of Chunghyul-dan(Qingxue-dan). Systolic TPR and SI was 0.87 and 1.04 in group A. Antihypertensive rate was higher in group A. Conclusion: These results suggest that 1200mg doses of Clunghyul-dan(Qingxue-dan) is an effective antihypertensive agent on stage 1 hypertension patients who have suffered a stroke.

Keywords

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