The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Antidepressant effect of Sayuksan and its influence on monoamines of depression model rats

四逆散의 抗憂鬱效果 및 腦內 monoamine에 미치는 영향

Shin Hwa-Suk;Kweon Young-Mo;Park Sun-Dong
신화석;권영모;박선동

  • Published : 20040000

⟨ Previous Next ⟩

Abstract

Objective: The purpose of this study was to reseach antidepressant effect and influence on monoamines of Sayuksan which is thought to have some antidepressant according to oriental medicine theory. Methods: We used "forced swimming test(FST)" to know antidepressant effect of Sayuksan and HPLC to check the influence on monoamines and their metabolites(norepinephrine, dopamine, DOPAC, HVA, serotonin. 5-HIAA) of Sayuksan after divided into cerebral cortex, striatum, hypothalamus and hippocampus Results: In the study of antidepressant effect by "forced swimming test(FST)" method, Sayuksan had a significant antidepressant effect. In the study of influence on monoammes by HPLC, Sayuksan mainly increased dopamine and serotonin signigficantly among monoamines in 4 parts of rat's brain above-mentioned. Conclusion: These results suggest that Sayuksan has antidepressant effect that may be related with the increase of dopamine and serotonin as its mechanism.

Keywords

References

  1. Eur J Pharmacol v.57 Immobility induced by forced modify central catecholamine and serotonin activity. Porsolt, R.D.;Anton, G.; Blavet, N.;Daniel, M.;Jalfre, M.
  2. 생리학 성호경(외)
  3. Biol Psychiatry v.46 Elevated level of tyrosine hydroxylase in the locus coeruleus in major depression. Zhu et al.
  4. 우울증의 동물모형으로서 CMS처치가 흰쥐의 수동회피학습에 미치는 효과 v.6 no.3 현성용
  5. Neuron. v.34 Neurobiology of depression. Eric J et al.
  6. Psychopharmacol. v.49 Animal models of edpression Willner, P.
  7. 중위뇌병중치 여광영
  8. 동의신경정신과학 김상효
  9. 신경해부학 신문균
  10. 방제학 김상찬(외)
  11. 생리학 의과대학 교수편
  12. 대한정신약물학회지． v.l2 no.1 에타베린의 항우울효과 이상경(외)
  13. 우울증의 신경생물학적 최신지견 생화학 뉴스 v.22 no.2 남윤영(외)
  14. 이우주의 약리학강의 3판 홍사석
  15. 精神醫學 李定均
  16. 중의임상상용대약배오 소경영
  17. 임상배합본초학 강병수;김영판
  18. 주해상한론 성무기