The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

An Experimental study on the Synergic Effect on Jawoongo and Gentamicin in Dermal Wound Healing and Skin Wound Infection against Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa

紫雲膏와 Gentamicin 倂用이 創傷治療 및 創傷感染에 미치는 影響에 關한 硏究

Kim, Su-Kyung;Choi, Hae-Yun;Jee, Seon-Young;Lee, Sang-Kon
김수경;최해윤;지선영;이상곤

  • Published : 20040000

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Abstract

Objectives : The purpose of this study is to evaluate the synergic effect of Jawoongo(紫雲膏) with gentamicin. Methods: The minimal inhibitory concentration(MIC), MIC50 and MIC90 of single use of gentamicin and Jawoongo with their concomitant treatment against 3 strains of bacteria, Staphylococcus aureus(S. aureus), Streptococcus pyogenes( S. pyogenes), Pseudomonas aeruginosa(P. aeruginosa) were observed. In addition, changes of wound size(CT50), viable bacterial numbers, total white blood cell(WBC) count and WBC differential count were also monitored after experimental excision skin wound infection mouse models with S. aureus ATCC 25923, S pyogens NCTC 10662 and P. aeruginosa ATCC 8668. Result : 1. In concomitant treatment of gentamicin and Jawoongo, relatively favorable antibacterial effects were Jawoongo-dose dependently demonstrated against three strains. 2. In concomitant treatment of gentamicin and Jawoongo, relatively favorable decrease of wound size were Jawoongo-dose-dependently demonstrated. 3. In concomitant treatment of gentamicin and Jawoongo, relatively decrease of CT50 was Jawoongo dose-dependently demonstrated in all tested models. 4. In concomitant treatment of gentamicin and Jawoongo, significantly decrease of decrease of WBC numbers neutrophil and monocytes, and increase of lymphocytes were Jawoongo-dose -dependently demonstrated in all tested models. 5. In concomitant treatment of gentamicin and Jawoongo, significantly decrease of viable bacterial numbers were Jawoongo-dose-dependently demonstrated in all tested models. Conclusion: Based on the above results, in concomitant treatment of gentamicin and Jawoongo, dual effect to antibacterial activities and accelerating effect of wound healing were demonstrated with synergic effect.

Keywords

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