The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Studies on the allergy asthma effect of Folium Perillae

蘇菜에 의한 알레르기 천식효과에 대한 연구

Kang, Yong-Sung;Lee, Seong-Cheol;Shin, Ho-Dong;Shin, Min-kyo;Kim, Jae-Hong;Song, Ho-Joon
강영성;이성철;신호동;신민교;김재홍;송호준

  • Published : 20040000

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Abstract

Objectives : To evaluate effect of allergy by Folium Perillae (FP), the biochemical changes associated with allergy were measured in BALF, serum, splenocyte and lung of mice. Methods: After induction of allergic inflammation asthma by treatment of ovalbumine, water extracts FP were taken orally for five successive days on mice, respectively. Results: In the total cell of BALF, the FP extract treated group was not significantly, reduced compared to control level, but the reduction of eosinophil showed significantly at concentration of 100 and l000 mg/kg,b.w. On the other hand, substantial decrease in IgE antibody formation was significantly observed by administration with FP extract (300, 1000mg/kg), whereas IgGl was not affected. IgG2a antibody formation appeared to be decreased in serum from FP treated mice. The content of IL-4, IL-5 exhibited physiological role in lung was significantly reduced compared to control group after treatment of FP extract(300, l000mg/kg). IL-4 in splenocyte, FP extract was all significantly reduced compared to control group and IL-5 was significantly reduced at concentration of FP extract (300, l000mg/kg). Conclusions: From the above result, it could be concluded that Folium Perillae showed beneficial effect on the al1ergic asthma.

Keywords

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