The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Studies on the mechanism of the anti-inflammatory effect of the Mudanpli(Cortex Moutan Radicis)

牧丹皮의 抗炎效果에 關한 硏究

Rho, Young-Deuk;Sim, Young-Seop;Song, Ho-Joon;Shin, Min-kyo
노영득;심영섭;송호준;신민교

  • Published : 20040000

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Abstract

Objectives: In an effort to elucidate the mechanism of the anti-inflammatory effect of the Mudanpli (Cortex Moutan Ra야cis : the root cortex of Paeonia suffruticosa Andrews; Ranunculaceae), I determined the effects of the methanolic extract of Mudanpli (MEM) on the secretions of interleukin(IL)-8, a major mediator of acute neutrophil-mediated inflammation, and macrophage chemoattractant protein (MCP)-1, a major mediator of chronic macrophage-mediatted inflammation, in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA). Methods : We were experimented IL-8, MCP-l secretion, $NF-{\kappa}B$ activity, MTT assay, RT-PCR. Results: MEM significanly inhibited PMA-induced secretions of IL-8 and MCP-l in a dose-dependent manner. The inhibitions of these chemokines by MEM were due to suppressions of IL-8 and MCP-1 genes. In addition, pentagalloylglucose (PGG), one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 by suppressing IL-8 and MCP-1 genes via $NF-{\kappa}B$ B inactivation. Conlusioos : From the above result, MEM was found to have a anti-inflammatory effect.

Keywords

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