Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
권호 표지

The Effects of Soopung-Hwan(Soufengwan) & CL(Caesalainiae Lignum) added to Soopung-Hwan(Soufengwan) on the Carrageenan-induced Arthertic Rats in terms of the Anti-Inflammatory, Analgesic and Anti-febrile Activeties

搜風丸 및 搜風丸加蘇木이 Carrageenan 유발 흰쥐 관절염의 소염, 진통 및 해열작용에 미치는 영향

Jee, Myung-Chul;Keum, Dong-Ho;Lee, Myeong-Jong
지명철;금동호;이명종

  • Published : 20040000

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Abstract

Objectives: This study was designed to examine the effects of Soopung-Hwan(Soufenwan) & CL added to Soopung-Hwan(Soufenwan) on the carrageenan-induced arthritic rats of terms of the anti-inflammatory, analgesic and anti-febrile activities. Method and Meterials : Each of the 7 rats was divided into a nomal, control, and sample group for the experiment conducted to test the anti-inflammatory, analgesic and the anti-febrile activity. Soopung-Hwan(Soufenwan) was administered orally to the sample group and normal saline was administered to the normal and the control group. Arthritis was induced by injecting 0.1$m{\ell}$ of 1% carrageenan per rat and Soopung-Hwan(Soufenwan) & CL added to Soopung-Hwan(Soufenwan) was administered after 30 minutes from the injection. The change of edema in Carrageenan-induced Arthritic Rats' Paws was measured after 1 hour and 5 hours from the injection of carrageenan with Plethysmometer(7150, UGO BASILE, Italy) by the method of winter. Writhing syndrom was measured with Tail flick unit(UGO BASILE, Italy) in the experiments conducted to test the analgesic, activity. The temperature was measured with Telethermometet afrer 5 hours from the injection of carrgeenan on the rat's paw and the recturm. Results : 1. In the sample groups, the increase retes of edema were effectively controlled with those of the control group. 2. In the sample groups, WBC, Neutrophil & Lymphocyte segment were effectively controled compared with those of the control group, and GOT, ALP were decreased and GPT was increased compared with those of the control group but signigicant. 3. In the sample groups, while the analgesic effect was shown in the CL added to Soopung-Hwan(Soufenwan) adminitered group, it was not in the Soopung-Hwan(Soufenwan) adminitered group. 4. in the sample groups, the temperature on the paw and the rectum was decreased effectively compared with the control group. Conclusion : It was recognized that Soopung-Hwan(Soufenwan) & CL added to Soopung-Hwan(Soufenwan) decreased edema, WBC, GOT, and ALP of the carrageenan-induced arthritic rats, controlled Neutrolled Neutrophil & Lymphocyte segment effectvely and showed the significant effectiveness in terms of the anti-febrile activity. It was recognized that Soopung-Hwan(Soupenwan) & CL added to Soopung-Hwan(Soufenwan) were considerably effective in terms of the anti-inflammatory activity. It was recognized that CL aedde to Soopung-Hwan(Soufenwan) was more effective than Soopung-Hwan(Soufenwan) in term of the analgesic activity. According to the above results, it can be concluded that Soopung-Hwan(Soufenwan) & CL added to Soopung-Hwan(Soufenwan) treated the caeeageenan-induced arthritic rets effectively in rerms of the anti-inflamatory, analgesic and anti-febrile activities. It is suggested that an additional study on side effects of the two prescriptions be conducted since properties of esch element of them are know as acute and severe.

Keywords

References

  1. 編註醫學入門(外集卷二) 李천
  2. 병리학 대한병리학회
  3. 東醫再活醫學科學 全國韓醫科大學 再活醫學科學敎室(編)
  4. 晴崗醫鑑 金永勳
  5. 간계내과학 전국한의과대학 간계내과학교실
  6. 醫部全錄(8) 陣夢雷;蔣廷錫(外)
  7. 景岳全書(上) 張景岳
  8. 醫宗金鑒(中) 誤廉(外)
  9. 丹溪心法附餘(下) 朱震亨
  10. 本草學 李尙仁
  11. 本草備要解析 楊東喜
  12. 동국대학교 대학원 박사학위논문 淸熱瀉濕湯이 관절염의 소염, 진통 및 해열작용에 미치는 영향 韓乙珠
  13. 대전대학교 대학원 석사학위논문 淸熱瀉濕湯이 MSU로 유발된 횐쥐의 痛風(Gout)에 미치는 實驗的 硏究 崔珍鳳
  14. 경희한의대논문집 v.7 淸熱瀉濕湯과 加味方의 鎭痛, 解熱, 消炎 및 利尿效果에 관한 實驗的 硏究 盧宗植
  15. 대전대학교 대학원 석사학위논문 檳蘇散과 三氣飮이 Adjuvant關節炎에 미치는 實驗的 硏究 전경택
  16. 경희대학교 대학원 석사학위논문 檳蘇散과 加味檳蘇散의 鎭痛.鎭靜.解熱 및 消炎作用에 關한 實驗的 硏究 송용선
  17. 경희대학교 대학원 석사학위논문 檳蘇散과 加未檳蘇散이 鎭痛 및 消炎作用에 미치는 影響 박웅덕
  18. 대전대학교 대학원 석사학위논문 檳蘇散加味方이 류마토이드 關節炎患者의 fibroblast-like synoviocytes에서 免疫反應에 미치는 影響 李仲徽
  19. 동의대학교 대학원 석사학위논문 當歸拈痛湯이 collagen誘發 關節淡에 미치는 影響 이채훈
  20. 대전대학교 대학원 석사학위논문 獨活奇生湯加猫脛骨이 Adjuvant 關節炎에 미치는 實驗的 硏究 徐海卿
  21. 경희대학교 대학원 석사학위논문 痺症治療에 응용되는 獨活寄生湯의 鎭痛, 消炎作用에 관한 實驗的 硏究 金瑩洙
  22. 동국대학교 대학원 박사학위논문 羌活續斷湯이 Adjuvant 誘發 關節炎 動物 model에 미치는 影響 金槿燦
  23. 경원대학교 대학원 석사학위논문 桃仁, 蘇木이 Endotoxin으로 誘發된 瘀血病態모델에 미치는 영향 高承希
  24. 경원대학교 대학원 석사학위논문 蘇木, 大黃이 Endotoxin으로 誘發된 瘀血病態模型에 미치는 영향 洪性寬
  25. 경원대학교 대학원 석사학위논문 桃仁, 蘇木이 Endotoxin으로 誘發되는 血栓에 미치는 영향 金孝宣
  26. 경원대학교 대학원 석사학위논문 蘇木, 當歸尾가 血栓症에 미치는 영향 金義鍾
  27. 東醫寶鑑 許淺
  28. Exph. Therap. Proc. Soc. Exp. Biol. and Med. v.111 Winter, C.A.;Risley, E.A.;Nuss, G.W.;Pharmacol, J.
  29. 정형외과학 대한정형외과학회
  30. 鍼灸學 全國韓醫科大學 鍼灸經穴學敎室(編)
  31. Cand. J. Pharm. Soc. v.2 Carrageenan structure and biological activity Anderson, W.
  32. J. Biol. Chem. v.201 Ascorbic acid and the formation of collagen Robertson, W.;Van, B.;Schwartz, B.
  33. J. Exp. Med. v.148 Mononuclear Phagocytes from carrageenan induced granulomas Bonney, R.J.;Grey, I.;Lin, T.;Meyenhofer, M.F.;Acevedo, W.;Davies, P.
  34. J. Exp. Path. v.49 The carrageenan granuloma in the rat. Brit Monis, B.;Weinberg, T.;Spector, G.J.
  35. Lab. Invest. v.22 Collagen resorption in carrageenan granulomas. I. Collagenolytic activity in vitro explants Perez-Tamayo, R.
  36. Pain v.32 A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia Hargreaves, K.;Dubner, R.;Brown, f.;Flores, C.;Joris, J.
  37. Am. J. Path. v.64 Spectrum and possible mechanism of carrageenan cytotoxicity Catanzaro, P.I.;Schwartz, H.J.;Graham, R.C.
  38. J. Exp. Med. v.124 An examination of the cytotoxic effects of silica on macrophage Allison, A.C.;Harrington, J.S.;Birbeck, M.
  39. 전남대학교 대학원 박사학위논문 Carrageenan으로 誘發한 關節炎 滑液膜의 光學 및 電子顯微鏡的 觀察 魏聖敏
  40. 임상병리파일 이귀녕;권오현
  41. 임상검사진단학 김순호;손한철;이은엽;장철훈