The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Antibacterial Activity of Combination use of Jengjengamiygin tang and Clarithromycin against Helicobacter pylori

正傳加味二陳湯과 clarithromycin의 倂用이 Helicobacter pylori에 미치는 영향

Kwak, Min-Ah;Seo, Bu-Il;Byun, Joon-Seok
곽민아;서부일;변준석

  • Published : 20040000

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Abstract

Objectives : To evaluate the antibacterial and synergic effects of Jengjengamiygin-tang(JJGM) with clarithromycin by in Vitro and in Vivo methods. Methods : The minimal inhibitory concentration(MIC), $MIC_{50}\;and\;MIC_{90}$ of single use of clarithromycin, JJGM and their concomitant treatment against Helicobacter pylori were observed. In addition, the changes of ulcerative lesions and viable cell numbers were also monitored after having experimented gastric infected mice models with Helicobacter pylori. Results: 1. The concomitant treatment of clarithromycin and JJGM showed relatively more favorable antibacterial effects than those of each. 2. The numbers of ulcerative lesions were more effectively inhibited by combination use of clarithromycin and JJGM. 3. The numbers of viable Helicobacter pylori were more effectively inhibited by combination use of clarithromycin and JJGM. Conclusions : The concomitant treatment of clarithromycin and JJGM showed relatively more favorable antibacterial effects than those of each.

Keywords

References

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