Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Resveratrol Induces Apoptosis in SW 480 Human Colon Cancer Cell Lines

Lee, Hyun-Sook;Sur, Eun-Young;Kim, Woo-Kyoung

  • Published : 20040200
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Abstract

Resveratrol, (3,4', 5-trans-trihydroxystilbene), a phytoalexin present in fruits and vegetables, possesses potent anti-inflammatory and anti-tumor activities. Effects of resveratrol on protein expressions of caspase-3, Bcl-2, Bax, total Akt and phosphorylated Akt, ErbB2, and ErbB3 in SW480 human colon cancer cell were investigated using SW480 cells cultured with various concentrations (0, 2.5, 5, 7.5, and $10{\mu}M$) of resveratrol. Resveratrol inhibited colon cancer cell growth in a dose-dependent manner (p<0.05), and increased caspase-3 expression. Bax expression was significantly increased and Bcl-2 levels were dose-dependently decreased in resveratrol-treated cells (p<0.05). Phosphorylated Akt, total Akt, ErbB2, and ErbB3 levels were markedly lower in $5{\mu}M$ resveratrol-treated cells (p<0.05). Results reveal resveratrol inhibits cell growth and induces apoptosis in SW480 human colon cancer cell lines via ErbB2/Akt signal pathway.

Keywords

References

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