Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Effects of Onion Extracts on Both Normal and Neoplastic Cell Proliferation and the Inhibition of Tumor Growth in Mouse

Han, Dae-Seok;Han, Jee-Hye;Oh, Se-Wook;Rho, Sook-Nyung

  • Published : 20040600
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Abstract

Cytotoxicity of four onion extracts on human cancer and normal cell lines was studied based on cell growth. Hexane fraction significantly inhibited growth of cancer cell lines dose-dependently ($IC_{50}$ values of 0.45 and 0.48 mg/mL for colon carcinoma SNU-C5 and lung carcinoma NCl-H1299, respectively). All onion extracts showed little effect on growth of normal cell lines except inhibition of 1.0 mg/mL hexane fraction on growth of normal colon cell CCD-18Co. Oral administration (15 days) of hexane fraction ($3{\mu}g/g$ body weight/day) to ICR mice bearing transplanted sarcoma 180 delayed appearance of macroscopic ascites and prolonged animal survival (p<0.05). Adaptogenic administration of hexane fraction starting before tumor inoculation ($7{\times}10^{6}$ cells, intraperitoneally) was more effective in terms of ascites appearance and animal survival. Hexane fraction of onion prevented ascites appearance in animal model.

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References

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